ArticleNature communications2017
Sulfur availability regulates plant growth via glucose-TOR signaling.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 168 citations in OpenAlex.
- Defining the Molecular Impacts of Humalite Application on Field-Grown Wheat (Triticum aestivum L.) Using Quantitative Proteomics.Proteomics · 2025Article
- Metabolite Profile and Metabolic Network Analysis of Walnuts (Metabolites · 2025Article
- Analysis of the quadruple lsu mutant reveals molecular determinants of the role of LSU proteins in sulfur assimilation in Arabidopsis.The Plant journal : for cell and molecular biology · 2024Article
- Genome-wide adenine N6-methylation map reveals epigenomic regulation of lipid accumulation in Nannochloropsis.Plant communications · 2024Article
- Autophagy in plants.Autophagy reports · 2024Review
- TORC pathway intersects with a calcium sensor kinase network to regulate potassium sensing inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatial expression patterns of genes encoding sugar sensors in leaves of C4 and C3 grasses.Annals of botany · 2023Article
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond.Journal of experimental botany · 2023Article
- Sulfur metabolism: actions for plant resilience and environmental adaptation.Journal of experimental botany · 2023Article
- ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis.Current biology : CB · 2023Article
- Interaction between Sulfate and Selenate in Tetraploid Wheat (International journal of molecular sciences · 2023Article
- Fine Tuning of ROS, Redox and Energy Regulatory Systems Associated with the Functions of Chloroplasts and Mitochondria in Plants under Heat Stress.International journal of molecular sciences · 2023Review
- Recent insights into metabolic and signalling events of directional root growth regulation and its implications for sustainable crop production systems.Frontiers in plant science · 2023Review
- The SLIM1 transcription factor affects sugar signaling during sulfur deficiency in Arabidopsis.Journal of experimental botany · 2022Article
- TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development.Journal of experimental botany · 2022Review
- The plant TOR kinase tunes autophagy and meristem activity for nutrient stress-induced developmental plasticity.The Plant cell · 2022Article
- Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7.The Plant cell · 2022Article
- Review: Emerging roles of the signaling network of the protein kinase GCN2 in the plant stress response.Plant science : an international journal of experimental plant biology · 2022Review
- Sulfur signaling and starvation response in Arabidopsis.iScience · 2022Review
- Linking Autophagy to Potential Agronomic Trait Improvement in Crops.International journal of molecular sciences · 2022Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2023-05-04Concerns/Issues about Results and/or Conclusions · Duplication of/in Image · Manipulation of Images · Original Data and/or Images not Provided and/or not Available ·
- Commented on by
- Retracted
Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth of eukaryotic cells is regulated by the target of rapamycin (TOR). The strongest activator of TOR in metazoa is amino acid availability. The established transducers of amino acid sensing to TOR in metazoa are absent in plants. Hence, a fundamental question is how amino acid sensing is achieved in photo-autotrophic organisms. Here we demonstrate that the plant Arabidopsis does not sense the sulfur-containing amino acid cysteine itself, but its biosynthetic precursors. We identify the kinase GCN2 as a sensor of the carbon/nitrogen precursor availability, whereas limitation of the sulfur precursor is transduced to TOR by downregulation of glucose metabolism. The downregulated TOR activity caused decreased translation, lowered meristematic activity, and elevated autophagy. Our results uncover a plant-specific adaptation of TOR function. In concert with GCN2, TOR allows photo-autotrophic eukaryotes to coordinate the fluxes of carbon, nitrogen, and sulfur for efficient cysteine biosynthesis under varying external nutrient supply.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.