ArticleScientific reports2017
Behaviorally-determined sleep phenotypes are robustly associated with adaptive functioning in individuals with low functioning autism.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neurodevelopmental spectrum of CASK-related disorder.Journal of neurodevelopmental disorders · 2025Pooled it
- Sleep Disturbances in Children and Adolescents with Autism Spectrum Disorder: A Scoping Review of Clinical Features, Impact and Interventions.Indian journal of psychological medicine · 2026Review
- Latent Profile Analysis of Sleep Patterns in Children With Autism Spectrum Disorder.Pediatric discovery · 2026Article
- Article
- Autism Spectrum Disorder Phenotypes Based on Sleep Dimensions and Core Autism Symptoms.Journal of autism and developmental disorders · 2025Article
- Genomic dissection of sleep archetypes in a large autism cohort.medRxiv : the preprint server for health sciences · 2025Article
- Identification of subgroups of children in the Australian Autism Biobank using latent class analysis.Child and adolescent psychiatry and mental health · 2023Article
- Sleep Problems and 6-Sulfatoxymelatonin as Possible Predictors of Symptom Severity, Adaptive and Maladaptive Behavior in Children with Autism Spectrum Disorder.International journal of environmental research and public health · 2022Article
- Examining the Relationship Between Sleep Quality, Social Functioning, and Behavior Problems in Children with Autism Spectrum Disorder: A Systematic Review.Nature and science of sleep · 2022Review
- Autism Spectrum Disorder and Intellectual Disability: A Pilot Study Exploring Associations between Child Sleep Problems, Child Factors and Parent Factors.International journal of environmental research and public health · 2021Article
- The chromatin remodeler ISWI acts duringScience advances · 2021Article
- Irregular Sleep/Wake Patterns Are Associated With Reduced Quality of Life in Post-treatment Cancer Patients: A Study Across Three Cancer Cohorts.Frontiers in neuroscience · 2021Article
- A Review of Sleep Disturbances among Infants and Children with Neurodevelopmental Disorders.Review journal of autism and developmental disorders · 2020Article
- Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults.Scientific reports · 2020Article
- Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review.Frontiers in psychiatry · 2018Review
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Despite sleep disturbance being a common complaint in individuals with autism, specific sleep phenotypes and their relationship to adaptive functioning have yet to be identified. This study used cluster analysis to find distinct sleep patterns and relate them to independent measures of adaptive functioning in individuals with autism. Approximately 50,000 nights of care-giver sleep/wake logs were collected on school-days for 106 individuals with low functioning autism (87 boys, 14.77 ± 3.11 years) for 0.5-6 years (2.2 ± 1.5 years) from two residential schools. Using hierarchical cluster analysis, performed on summary statistics of each individual across their recording duration, two clusters of individuals with clearly distinguishable sleep phenotypes were found. The groups were summarized as 'unstable' sleepers (cluster 1, n = 41) and 'stable' sleepers (cluster 2, n = 65), with the former exhibiting reduced sleep duration, earlier sleep offset, and less stability in sleep timing. The sleep clusters displayed significant differences in properties that were not used for clustering, such as intellectual functioning, communication, and socialization, demonstrating that sleep phenotypes are associated with symptom severity in individuals with autism. This study provides foundational evidence for profiling and targeting sleep as a standard part of therapeutic intervention in individuals with autism.
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Registered trials
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