ArticleScientific reports2017
Limiting Injury During Saphenous Vein Graft Preparation For Coronary Arterial Bypass Prevents Metabolic Decompensation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Effectiveness of a Rotating-Leg Prepper for Reducing Pressure Injury and Preventing Surgical Site Infection in Patients Undergoing Heart Surgery: Paired Matching Randomised Controlled Trial.International wound journal · 2025Trial
- The Predictive Value of Pan-Immune-Inflammation Value for Saphenous Vein Graft Disease in Post-Coronary Artery Bypass Grafting Patients.Journal of cardiovascular development and disease · 2024Article
- Antithrombotic strategies for preventing graft failure in coronary artery bypass graft.Journal of thrombosis and thrombolysis · 2024Review
- Improvement of the outcome of the saphenous vein graft when connected to the internal thoracic artery.Frontiers in cardiovascular medicine · 2024Article
- Consensus statement-graft treatment in cardiovascular bypass graft surgery.Frontiers in cardiovascular medicine · 2024Article
- Impact of Age on Endothelial Function of Saphenous Vein Grafts in Coronary Artery Bypass Grafting.Journal of clinical medicine · 2023Article
- Graft thrombosis after coronary artery bypass surgery and current practice for prevention.Frontiers in cardiovascular medicine · 2023Review
- Effect of preservation solution and distension pressure on saphenous vein's endothelium.Interactive cardiovascular and thoracic surgery · 2022Article
- Saphenous vein grafts in contemporary coronary artery bypass graft surgery.Nature reviews. Cardiology · 2020Review
- The Role of Tomographic Ultrasonography in Conduit Mapping before Coronary Artery Bypass Grafting.Radiology research and practice · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Standard harvest and preparation of human saphenous vein (HSV) for autologous coronary and peripheral arterial bypass procedures is associated with injury and increased oxidative stress that negatively affect graft performance. In this study we investigated the global metabolomic profiles of HSV before (unprepared; UP) and after standard vein graft preparation (AP). AP-HSV showed impaired vasomotor function that was associated with increased oxidative stress, phospholipid hydrolysis and energy depletion that are characteristic of mechanical and chemical injury. A porcine model (PSV) was utilized to validate these metabolomic changes in HSV and to determine the efficacy of an improved preparation technique (OP) using pressure-regulated distension, a non-toxic vein marker, and graft storage in buffered PlasmaLyte solution in limiting metabolic decompensation due to graft preparation. Deficits in vasomotor function and metabolic signature observed in AP-PSV could be largely mitigated with the OP procedure. These findings suggest that simple strategies aimed at reducing injury during graft harvest and preparation represents a straightforward and viable strategy to preserve conduit function and possibly improve graft patency.
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