ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Optogenetic Inhibition Reveals Distinct Roles for Basolateral Amygdala Activity at Discrete Time Points during Risky Decision Making.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 69 citations in OpenAlex.
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- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Optogenetic inhibition reveals distinct contributions of medial prefrontal cortex to intertemporal choice in young and aged rats.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- A distinct hypothalamus-habenula circuit governs risk preference.Nature neuroscience · 2025Article
- Social Risk Coding by Amygdala Activity and Connectivity with the Dorsal Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The threshold moderating effect of self-efficacy: a nonlinear transformation mechanism of work passion on job satisfaction among sports practitioners.Frontiers in psychology · 2025Article
- Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood.Neurobiology of learning and memory · 2025Article
- Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Effects of optogenetic silencing the anterior cingulate cortex in a delayed non-match to trajectory task.Oxford open neuroscience · 2024Article
- Effects of reproductive experience on cost-benefit decision making in female rats.Frontiers in behavioral neuroscience · 2024Article
- Effects of fentanyl self-administration on risk-taking behavior in male rats.Psychopharmacology · 2023Article
- The rat frontal orienting field dynamically encodes value for economic decisions under risk.Nature neuroscience · 2023Article
- Circuit and Cell-Specific Contributions to Decision Making Involving Risk of Explicit Punishment in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Temporal Dynamics Underlying Prelimbic Prefrontal Cortical Regulation of Action Selection and Outcome Evaluation during Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A neural substrate of sex-dependent modulation of motivation.Nature neuroscience · 2023Article
- Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model.eNeuro · 2023Article
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7 authors at 2 institutions in 3 countries.
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Abstract
Decision making is a multifaceted process, consisting of several distinct phases that likely require different cognitive operations. Previous work showed that the basolateral amygdala (BLA) is a critical substrate for decision making involving risk of punishment; however, it is unclear how the BLA is recruited at different stages of the decision process. To this end, the current study used optogenetics to inhibit the BLA during specific task phases in a model of risky decision making (risky decision-making task) in which rats choose between a small, "safe" reward and a large reward accompanied by varying probabilities of footshock punishment. Male Long-Evans rats received intra-BLA microinjections of viral vectors carrying either halorhodopsin (eNpHR3.0-mCherry) or mCherry alone (control) followed by optic fiber implants and were trained in the risky decision-making task. Laser delivery during the task occurred during intertrial interval, deliberation, or reward outcome phases, the latter of which was further divided into the three possible outcomes (small, safe; large, unpunished; large, punished). Inhibition of the BLA selectively during the deliberation phase decreased choice of the large, risky outcome (decreased risky choice). In contrast, BLA inhibition selectively during delivery of the large, punished outcome increased risky choice. Inhibition had no effect during the other phases, nor did laser delivery affect performance in control rats. Collectively, these data indicate that the BLA can either inhibit or promote choice of risky options, depending on the phase of the decision process in which it is active.
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