ArticleNeurology2017
Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study.
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Exercise, exerkines, and muscle-brain crosstalk in Parkinson's disease.Neuroprotection (Chichester, England) · 2026Review
- When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- IntravenousJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Investigating the impact of body weight changes and blood lipids on risk for mild cognitive impairment in Parkinson's disease: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Explainable machine learning-driven models for predicting Parkinson's disease and its prognosis: obesity patterns associations and models development using NHANES 1999-2018 data.Lipids in health and disease · 2025Article
- Review
- Metabolic dysregulation and resistance to high-fat diet-induced weight gain in mice overexpressing human wild-type α-synuclein.NPJ Parkinson's disease · 2025Article
- Shaping Outcomes: Levodopa-Carbidopa Intestinal Gel Treatment and Nutrition in Parkinson's Disease-A Prospective Observational Cohort Study.Journal of clinical medicine · 2025Article
- The 6-OHDA Parkinson's Disease Mouse Model Shows Deficits in Sensory Behavior.bioRxiv : the preprint server for biology · 2025Article
- Review
- Unravelling the mechanisms of underweight in Parkinson's disease by investigating into the role of gut microbiome.NPJ Parkinson's disease · 2024Article
- Association Between Body Mass Index Changes and All-Cause Mortality in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments.Journal of cachexia, sarcopenia and muscle · 2023Review
- Weight and survival after deep brain stimulation for Parkinson's disease.Parkinsonism & related disorders · 2023Article
- Impact of weight loss for depressive symptom in mid-stage patients with Parkinson's disease: a 4-year follow-up study.Frontiers in neurology · 2023Article
- The effect of cardiovascular risk on disease progression inFrontiers in neurology · 2023Article
- Effects of a Resistance Training Protocol on Physical Performance, Body Composition, Bone Metabolism, and Systemic Homeostasis in Patients Diagnosed with Parkinson's Disease: A Pilot Study.International journal of environmental research and public health · 2022Article
- Clinical trajectories and biomarkers for weight variability in early Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Body mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's disease.Health science reports · 2022Article
- Sleep and circadian rhythms in Parkinson's disease and preclinical models.Molecular neurodegeneration · 2022Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo compare weight change over time in patients with Parkinson disease (PD), those with atypical parkinsonism, and matched controls; to identify baseline factors that influence weight loss in parkinsonism; and to examine whether it predicts poor outcome.
methodsWe analyzed data from the Parkinsonism Incidence in North-East Scotland (PINE) study, an incident, population-based prospective cohort of parkinsonian patients and age- and sex-matched controls with annual follow-up. Mixed-model analysis described weight change in patients with PD, those with atypical parkinsonism, and controls. Baseline determinants of sustained clinically significant weight loss (>5% loss from baseline) and associations between early sustained weight loss and death, dementia, and dependency in parkinsonism were studied with Cox regression.
resultsA total of 515 participants (240 controls, 187 with PD, 88 with atypical parkinsonism) were followed up for a median of 5 years. At diagnosis, atypical parkinsonian patients had lower body weights than patients with PD, who were lighter than controls. Patients with PD lost weight more rapidly than controls, and weight loss was most rapid in atypical parkinsonism. After multivariable adjustment for potential confounders, only age was independently associated with sustained clinically significant weight loss (hazard ratio [HR] for 10-year age increase 1.83, 95% confidence interval [CI] 1.44-2.32). Weight loss occurring within 1 year of diagnosis was independently associated with increased risk of dependency (HR 2.11, 95% CI 1.00-4.42), dementia (HR 3.23, 95% CI 1.40-7.44), and death (HR 2.23, 95% CI 1.46-3.41).
conclusionWeight loss occurs in early parkinsonism and is greater in atypical parkinsonism than in PD. Early weight loss in parkinsonism has prognostic significance, and targeted dietary interventions to prevent it may improve long-term outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.