Evidence map›Paper›PMID 29079660›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Dual mTOR Kinase Inhibitor MLN0128 Sensitizes HR

Pei-Yin Hsu, Victoria Shang Wu, Noriko Kanaya, Karineh Petrossian, Hang-Kai Hsu, Duc Nguyen, Daniel Schmolze, Masaya Kai, Chun-Yu Liu, Hannah Lu and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. The Breast Cancer Proteome and Precision Oncology.Cold Spring Harbor perspectives in medicine · 2023
    Review
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  9. Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Pei-Yin HsuDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Victoria Shang WuDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Noriko KanayaDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Karineh PetrossianDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Hang-Kai HsuDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Duc NguyenDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Daniel SchmolzeDepartment of Pathology, City of Hope Medical Center, Duarte, California.
Masaya KaiDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Chun-Yu LiuDepartment of Oncology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Hannah LuDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California.
Peiguo ChuDepartment of Pathology, City of Hope Medical Center, Duarte, California.
Courtney A VitoDepartment of Surgery, City of Hope Medical Center, Duarte, California.
Laura KruperDepartment of Surgery, City of Hope Medical Center, Duarte, California.
Joanne MortimerDepartment of Medical Oncology and Therapeutic Research, City of Hope Medical Center, Duarte, California.
Shiuan ChenDepartment of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California. schen@coh.org.
City Of Hope National Medical Center · USNational Yang Ming Chiao Tung University · TW

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
AROMATASE AND BREAST CANCERR01CA044735 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI CHEN, SHIUAN · 1988 to 2009
$4.0M
ENDOCRINE DISRUPTING CHEMICALS AND AROMATASER01ES008258 · NIEHS · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI CHEN, SHIUAN · 1996 to 2009
$2.6M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA044735NIEHS NIH HHS R01 ES008258
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineAnimalsBenzoxazolesBiomarkers, TumorBreast NeoplasmsCell Line, TumorDisease Models, AnimalErb-b2 Receptor Tyrosine KinasesEstrogensFemaleFulvestrantHumansImmunohistochemistryMiceMice, KnockoutProtein Kinase InhibitorsAdenineBenzoxazolesBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesEstrogensFulvestrantMTOR protein, humanProtein Kinase InhibitorsPyrimidinessapanisertibTOR Serine-Threonine KinasesTrastuzumab

Identifiers

PMID29079660
PMCPMC8820221
OpenAlexW2766702959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.