Evidence map›Paper›PMID 29079629›Full record

ArticleApplied and environmental microbiology2018

Plasticity of the Pyruvate Node Modulates Hydrogen Peroxide Production and Acid Tolerance in Multiple Oral Streptococci.

Xingqun Cheng, Sylvio Redanz, Nyssa Cullin, Xuedong Zhou, Xin Xu, Vrushali Joshi, Dipankar Koley, Justin Merritt, Jens Kreth

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. HApplied and environmental microbiology · 2026
    Article
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  5. Reproducible 3D bioprinting ofMicrobiology spectrum · 2025
    Article
  6. The role of salivary metabolomics in chronic periodontitis: bridging oral and systemic diseases.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Anti-Infection of Oral Microorganisms from Herbal Medicine ofDrug design, development and therapy · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Xingqun ChengDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Sylvio RedanzDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Nyssa CullinDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Xuedong ZhouThe State Key Laboratory of Oral Diseases and the National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xin XuThe State Key Laboratory of Oral Diseases and the National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Vrushali JoshiDepartment of Chemistry, Oregon State University, Corvallis, Oregon, USA.
Dipankar KoleyDepartment of Chemistry, Oregon State University, Corvallis, Oregon, USA.
Justin MerrittDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA.
Jens KrethDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon, USA kreth@ohsu.edu.
Oregon Health & Science University · USState Key Laboratory of Oral DiseasesOregon State University · USUniversity of Oklahoma Health Sciences Center · US

Funding

The IrvA-Dependent Pathway: A Link Between Stress Adaptation and VirulenceR01DE018893 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MERRITT, JUSTIN · 2009 to 2018
$3.0M
Pyruvate oxidase determines ecological fitness of oral streptococciR01DE021726 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI KRETH, JENS · 2014 to 2018
$1.9M
The LytTR Regulatory Systems of Streptococcus mutansR01DE022083 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MERRITT, JUSTIN · 2013 to 2016
$1.5M
NIDCR NIH HHS R01 DE018893NIDCR NIH HHS R01 DE021726NIDCR NIH HHS R01 DE022083
6 · The paper itself

Abstract

Commensal

Indexed as

AcidsBacterial ProteinsBiofilmsDental CariesDental PlaqueHumansHydrogen-Ion ConcentrationHydrogen PeroxideMouthPyruvic AcidStreptococcusStreptococcus gordoniiStreptococcus mutansStreptococcus sanguisStress, PhysiologicalAcidsBacterial ProteinsHydrogen PeroxidePyruvic Acidbiofilmsmicrobial ecologyStreptococcus

Identifiers

PMID29079629
PMCPMC5752870
OpenAlexW2765775811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.