ArticleHaematologica2018
Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.
Open access · goldAbstract read
In one paragraph
Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
117 citing papers in PubMed, 158 citations in OpenAlex.
- Blood-storage duration affects hematological and metabolic profiles in patients with sickle cell disease receiving transfusions.The Journal of clinical investigation · 2025Trial
- Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion.Blood advances · 2022Trial
- Stored RBC metabolism as a function of caffeine levels.Transfusion · 2020Trial
- Trial
- Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion.The Journal of clinical investigation · 2020Trial
- Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.Transfusion · 2018Trial
- The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2026Review
- A study on the impact of blood large-scale long-distance airdrop on storage quality of suspended red blood cells.Transfusion · 2026Article
- Acute pain transfusion reaction in a patient with thalassemia: In-depth characterization of short- and long-term phenotypes.Transfusion · 2026Article
- Analysis of purines and pyrimidines across biospecimens: influence of storage temperature and duration.Scientific reports · 2026Article
- Lower efficacy of transfusion of red blood cells from donors with sickle cell trait.HemaSphere · 2026Article
- Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity.Haematologica · 2026Article
- Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells.Blood red cells & iron · 2026Article
- Nucleotide salvage, genome instability, and potential therapeutic applications.Nucleic acids research · 2026Review
- The Immunology of Transfusion Medicine: Past, Present, and Future.Methods in molecular biology (Clifton, N.J.) · 2026Review
- High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026Article
- GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells.Blood red cells & iron · 2025Article
- Supercooled storage of red blood cells slows down the metabolic storage lesion.Scientific reports · 2025Article
- Differential Expression of Erythrocyte Proteins in Patients with Alcohol Use Disorder.International journal of molecular sciences · 2025Article
- Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units.JCI insight · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 2 countries.
Travis NemkovDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Kaiqi SunDepartment of Biochemistry, University of Texas Houston - School of Medicine, Houston, TX, USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Anren SongDepartment of Biochemistry, University of Texas Houston - School of Medicine, Houston, TX, USA.
Tatsuro YoshidaNew Health Sciences Inc, Boston, MA, USA.
Andrew DunhamNew Health Sciences Inc, Boston, MA, USA.
Matthew J WitherDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Richard O FrancisDepartment of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.
Robert C RoachAltitude Research Center, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Stephen C RogersDivision of Critical Care Medicine, Department of Pediatrics, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
Allan DoctorDivision of Critical Care Medicine, Department of Pediatrics, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
Anastasios KriebardisDepartment of Medical Laboratories, Technological and Educational Institute of Athens, Greece.
Marianna AntonelouDepartment of Biology, National and Kapodistrian University of Athens, Greece.
Issidora PapassideriDepartment of Biology, National and Kapodistrian University of Athens, Greece.
Carolyn T YoungRhode Island Blood Center, Providence, RI, USA.
Tiffany A ThomasDepartment of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Steven L SpitalnikDepartment of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.
Yang XiaDepartment of Biochemistry, University of Texas Houston - School of Medicine, Houston, TX, USA.
James C ZimringBloodWorks Northwest, Seattle, WA, USA.
Eldad A HodDepartment of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA angelo.dalessandro@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USColumbia University Irving Medical Center · USHemanext (United States) · USNational and Kapodistrian University of Athens · GRUniversity of Colorado Denver · USWashington University in St. Louis · USBloodworks Northwest · USRhode Island Blood Center · USTechnological Educational Institute of Athens · GR
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MTrauma Reprograms CellsP50GM049222 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI BANERJEE, ANIRBAN · 1993 to 2017
$26.1MMechanisms of Trauma-Induced CoagulopathyT32GM008315 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, ELIZABETH J. KOVACS · 1991 to 2026
$7.1MSEPSIS-INDUCED RED CELL DYSFUNCTION (SIRD)R01GM113838 · NIGMS · WASHINGTON UNIVERSITY · PI DOCTOR, ALLAN, MARSHALL, GARLAND ROSS · 2015 to 2019
$4.0MRegulatory Approval & Commercialization of an RBC Processing and Storage System to Improve Transfusion Therapy by Minimizing Oxidative Damage to RBC during StorageR44HL132172 · NHLBI · NEW HEALTH SCIENCES, INC. · PI DUNHAM, ANDREW, YOSHIDA, TATSURO · 2016 to 2018
$3.0MHarmful effects of red blood cell transfusions are mediated by ironR01HL115557 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPITALNIK, STEVEN L · 2013 to 2016
$2.3MMolecular insight of erythrocyte hypoxic metabolic reprogramming in chronic kidney diseaseR01HL137990 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2017 to 2018
$989kNCI NIH HHS P30 CA046934NHLBI NIH HHS R01 HL115557NHLBI NIH HHS R01 HL137990NHLBI NIH HHS R44 HL132172NIGMS NIH HHS P50 GM049222NIGMS NIH HHS R01 GM113838NIGMS NIH HHS T32 GM008315
Abstract
Hypoxanthine catabolism
Indexed as
HypoxiaAnimalsBlood PreservationDeaminationErythrocytesErythrocyte TransfusionHumansHypoxanthineMiceMice, Inbred C57BLPurinesHypoxanthinePurines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.