Evidence map›Paper›PMID 29079590›Full record

GuidelineAnnals of the rheumatic diseases2017

2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups.

Ingrid E Lundberg, Anna Tjärnlund, Matteo Bottai, Victoria P Werth, Clarissa Pilkington, Marianne de Visser, Lars Alfredsson, Anthony A Amato, Richard J Barohn, Matthew H Liang and 28 more

Erratum issued 2 registry-linked trialsOpen access · greenAbstract readConsensus StatementPractice GuidelineValidation Study
In one paragraph

Guideline in Annals of the rheumatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 721 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
721citing papers in PubMed, 2 pooled it
54.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05879419 phase4active not recruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy, Immunogenicity and Safety of Recombinant Vaccine Against Herpes Zoster (RZV or SHINGRIX®) in Patients With Autoimmune Rheumatic Diseases

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2023 to 2032Enrolled2,005ConditionsRheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus ErythematosusArmsRecombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation, Placebo, MTX maintain
NCT06887738 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Proof-of-Concept Phase II, Open-Label Study of NM8074 in Patients with Dermatomyositis (DM)

TypeinterventionalSponsorNovelMed TherapeuticsRan2026 to 2028Enrolled8ConditionsDermatomyositisArmsNM8074
3 · Its place in the literature

Who cites it

721 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,469 citations in OpenAlex.

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661 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 14 countries.

Ingrid E LundbergRheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Anna TjärnlundRheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Matteo BottaiInstitute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Victoria P WerthDepartment of Dermatology, Philadelphia VAMC and Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Clarissa PilkingtonDepartment of Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Marianne de VisserDepartment of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.
Lars AlfredssonInstitute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anthony A AmatoDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Richard J BarohnDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Matthew H LiangDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, and Section of Rheumatology, Boston VA Healthcare, Boston, Massachusetts, USA.
Jasvinder A SinghMayo Clinic College of Medicine, Rochester, Minnesota, USA.
Rohit AggarwalDivision of Rheumatology and Clinical Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Snjolaug ArnardottirDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Hector ChinoyNational Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, University of Manchester, Manchester, UK.
Robert G CooperMRC/ARUK Institute of Ageing and Chronic Disease, Faculty of Health & Life Sciences, University of Liverpool, Liverpool, UK.
Katalin DankóDivision of Immunology, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
Mazen M DimachkieDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Brian M FeldmanDivision of Rheumatology, Department of Pediatrics, University of Toronto and The Hospital for Sick Children, Toronto, Canada.
Ignacio Garcia-De La TorreDepartment of Immunology and Rheumatology, Hospital General de Occidente, Secretaría de Salud, and University of Guadalajara, Guadalajara, Jalisco, Mexico.
Patrick GordonDepartment of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK.
Taichi HayashiClinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
James D KatzNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.
Hitoshi KohsakaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Peter A LachenbruchDepartment of Public Health, Oregon State University, Corvallis, Oregon, USA.
Bianca A LangDivision of Rheumatology, Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, Canada.
Yuhui LiDepartment of Rheumatology and Immunology, People's Hospital of Beijing University, Beijing, China.
Chester V OddisDivision of Rheumatology and Clinical Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Marzena OlesinskaConnective Tissue Diseases Department, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Ann M ReedDepartment of Pediatrics, Duke University, Durham, North Carolina, USA.
Lidia Rutkowska-SakPaediatric Clinic of Rheumatology, Institute of Rheumatology, Warsaw, Poland.
Helga SannerSection of Rheumatology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Albert Selva-O'CallaghanVall d'Hebron General Hospital, Barcelona, Spain.
Yeong-Wook SongDepartment of Internal Medicine, Medical Research Center, Clinical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jiri VencovskyDepartment of Rheumatology, Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Steven R YtterbergDivision of Rheumatology, Mayo Clinic College of Medicine, Rochester, New York, USA.
Frederick W MillerUS Department of Health and Human Services, Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Lisa G RiderUS Department of Health and Human Services, Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, USA.
International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland)
Karolinska Institutet · SENational Institutes of Health · USBrigham and Women's Hospital · USNational Institute of Geriatrics, Rheumatology and Rehabilitation · PLUniversity of Kansas Medical Center · USUniversity of Pittsburgh · USAmsterdam UMC Location University of Amsterdam · NLBirmingham VA Medical Center · USCharles University · CZDalhousie University · CADuke University · USGreat Ormond Street Hospital · GBKarolinska University Hospital · SEKing's College Hospital NHS Foundation Trust · GBManchester University NHS Foundation Trust · GBMayo Clinic · USOregon State University · USOslo University Hospital · NOPeking University · CNPhiladelphia VA Medical Center · US

Funding

Clinical Support Services for the NIAMS Intramural Research ProgramZIDAR041180 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$119.2M
Environmental/genetic Risk Factors and Pathogenesis of Autoimmune DiseaseZIAES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$34.6M
Clinical Training in RheumatologyZIEAR041176 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$29.8M
Assessment, Therapy and Prevention Of Autoimmune DiseaseZIAES101081 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$17.6M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES101074Medical Research Council MR/N003322/1Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

objectiveTo develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups.

methodsCandidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology and paediatric clinics worldwide. Several statistical methods were used to derive the classification criteria.

resultsBased on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cut-off of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) 'probable IIM', had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of ≥90%, corresponding to a score of ≥7.5 (≥8.7 with muscle biopsy), corresponds to 'definite IIM'. A probability of <50%, corresponding to a score of <5.3 (<6.5 with muscle biopsy), rules out IIM, leaving a probability of ≥50 to <55% as 'possible IIM'.

conclusionsThe European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology and paediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of 'definite', 'probable' and 'possible' IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria.

Indexed as

AdultBiopsyChildConsensusDiagnosis, DifferentialEuropeHumansMuscle, SkeletalMyositisProbabilityReference ValuesRheumatologySensitivity and SpecificitySocieties, MedicalUnited Statesautoimmune diseasesdermatomyositispolymyositis

Identifiers

PMID29079590
PMCPMC5736307
OpenAlexW2765743865

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.