ArticleJournal of the American Heart Association2017
Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter-Free Ablation of Cardiac Arrhythmias.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Phase I/II Trial of Electrophysiology-Guided Noninvasive Cardiac Radioablation for Ventricular Tachycardia.Circulation · 2019Trial
- Standardized processing of explanted hearts after stereotactic arrhythmia radiotherapy (Bio-STAR): a STOPSTORM framework and first human findings.European heart journal open · 2026Article
- STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study.Circulation. Arrhythmia and electrophysiology · 2025Article
- Robotic-Assisted Solutions for Invasive Cardiology, Cardiac Surgery and Routine On-Ward Tasks: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
- Septal radioablation therapy for patients with hypertrophic obstructive cardiomyopathy: first-in-human study.European heart journal open · 2023Article
- Stereotactic Arrhythmia Radioablation Treatment of Ventricular Tachycardia: Current Technology and Evolving Indications.Journal of cardiovascular development and disease · 2023Review
- The Use of Cardiac Stereotactic Radiation Therapy (SBRT) to Manage Ventricular Tachycardia: A Case Report, Review of the Literature and Technical Notes.Journal of personalized medicine · 2022Article
- Stereotactic Radiotherapy: An Alternative Option for Refractory Ventricular Tachycardia to Drug and Ablation Therapy.Journal of clinical medicine · 2022Review
- Non-invasive Stereotactic Body Radiation Therapy for Refractory Ventricular Arrhythmias: Venturing into the Unknown.The Journal of innovations in cardiac rhythm management · 2022Article
- Successful ventricular tachycardia radioablation in a patient with previous chemical pleurodesis: A case report.Frontiers in cardiovascular medicine · 2022Article
- The effect of ionizing radiation through cardiac stereotactic body radiation therapy on myocardial tissue for refractory ventricular arrhythmias: A review.Frontiers in cardiovascular medicine · 2022Review
- One-Week Dynamic Changes in Cardiac Proteomes After Cardiac Radioablation in Experimental Rat Model.Frontiers in cardiovascular medicine · 2022Article
- Article
- Non-invasive stereotactic body radiation therapy for refractory ventricular arrhythmias: an institutional experience.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- A proof of concept treatment planning study of gated proton radiotherapy for cardiac soft tissue sarcoma.Physics and imaging in radiation oncology · 2021Article
- Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model.Scientific reports · 2021Article
- Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation.Journal of the American Heart Association · 2021Article
- Review of Stereotactic Arrhythmia Radioablation Therapy for Cardiac Tachydysrhythmias.CJC open · 2021Review
- Stereotactic Ablative radiation therapy (SABR) for cardiac arrhythmia: A new therapeutic option?La Radiologia medica · 2021Review
- Stereotactic Cardiac Radiation to Control Ventricular Tachycardia and Fibrillation Storm in a Patient with Apical Hypertrophic Cardiomyopathy at Burnout Stage: Case Report.Journal of Korean medical science · 2020Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLinear accelerator-based stereotactic radiosurgery delivered to cardiac arrhythmogenic foci could be a promising catheter-free ablation modality. We tested the feasibility of in vivo atrioventricular (AV) node ablation in swine using stereotactic radiosurgery. METHODS AND
resultsFive Large White breed swine (weight 40-75 kg; 4 females) were studied. Single-chamber St Jude pacemakers were implanted in each pig. The pigs were placed under general anesthesia, and coronary/cardiac computed tomography simulation scans were performed to localize the AV node. Cone beam computed tomography was used for target positioning. Stereotactic radiosurgery doses ranging from 35 to 40 Gy were delivered by a linear accelerator to the AV node, and the pigs were followed up with weekly pacemaker interrogations to observe for potential electrocardiographic changes. Once changes were observed, the pigs were euthanized, and pathology specimens of various tissues, including the AV node and tissues surrounding the AV node, were taken to study the effects of radiation. All 5 pigs had disturbances of AV conduction with progressive transition into complete heart block. Macroscopic inspection did not reveal damage to the myocardium, and pigs had preserved systolic function on echocardiography. Immunostaining revealed fibrosis in the target region of the AV node, whereas no fibrosis was detected in the nontargeted regions.
conclusionsCatheter-free radioablation using linear accelerator-based stereotactic radiosurgery is feasible in an intact swine model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.