Observational studyJournal of the American Heart Association2017
Forward Left Ventricular Ejection Fraction: A Simple Risk Marker in Patients With Primary Mitral Regurgitation.
Observational study in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01835054 (Determinants of the Progression and Outcome of Mitral Regurgitation-PROGRAM STUDY), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determinants of the Progression and Outcome of Mitral Regurgitation-PROGRAM STUDY
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Advanced Imaging Assessment of the Impact of Tricuspid Regurgitation on Cardiac Remodeling: The TRILUMINATE Pivotal Imaging Substudy.Journal of the American College of Cardiology · 2025Trial
- Left ventricular stroke volume index predicts outcomes in asymptomatic chronic severe primary mitral regurgitation.Journal of cardiovascular imaging · 2026Article
- Cardiopulmonary Exercise Testing and Exercise Stress Echocardiography in Degenerative Mitral Regurgitation: An Exploratory Analysis of Functional and Left Ventricular Outcomes After Surgery.Journal of cardiovascular development and disease · 2026Article
- EuroSCORE II: Current limitations and physiological gaps in risk stratification.Experimental physiology · 2026Review
- Noninvasive Myocardial Work Predicts Long-Term Postinterventional Outcomes in Patients With Primary Mitral Regurgitation.Journal of the American Heart Association · 2025Article
- Prognostic Value of the Global Left Ventricular Contractility Index in Patients with Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction.Journal of cardiovascular development and disease · 2025Article
- Forward Flow in Patients With Heart Failure and Functional Mitral Regurgitation: The COAPT Trial.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Prognostic Value of Pre-Operative Transthoracic Echocardiography in Patients with Primary Mitral Regurgitation.Reviews in cardiovascular medicine · 2024Review
- Left and Right Ventricular Hemodynamic Response After Transcatheter Mitral Valve Replacement.Structural heart : the journal of the Heart Team · 2024Article
- Short-term mechanical support with the Impella 5.x for mitral valve surgery in advanced heart failure-protected cardiac surgery.Frontiers in cardiovascular medicine · 2023Article
- Prognostic value of forward flow indices in primary mitral regurgitation due to mitral valve prolapse.Frontiers in cardiovascular medicine · 2023Article
- Cardiac Damage Staging Classification in Asymptomatic Moderate or Severe Primary Mitral Regurgitation.Structural heart : the journal of the Heart Team · 2022Article
- Management of circulatory failure after Fontan surgery.Frontiers in pediatrics · 2022Review
- Mitral valve repair in chronic severe mitral regurgitation: short-term results and analysis of mortality predictors.Indian journal of thoracic and cardiovascular surgery · 2021Article
- Forward Left Ventricular Ejection Fraction as a Predictor of Postoperative Left Ventricular Dysfunction in Patients with Degenerative Mitral Regurgitation.Journal of clinical medicine · 2021Article
- Invasive left ventricle pressure-volume analysis: overview and practical clinical implications.European heart journal · 2020Review
- Global longitudinal strain: is it a superior assessment method for left ventricular function in patients with chronic mitral regurgitation undergoing mitral valve replacement?Indian journal of thoracic and cardiovascular surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe timing of mitral valve surgery in asymptomatic patients with primary mitral regurgitation (MR) is controversial. We hypothesized that the forward left ventricular (LV) ejection fraction (LVEF; ie, LV outflow tract stroke volume divided by LV end-diastolic volume) is superior to the total LVEF to predict outcomes in MR. The objective of this study was to examine the association between echocardiographic parameters of MR severity and LV function and outcomes in patients with MR. METHODS AND
resultsThe clinical and Doppler-echocardiographic data of 278 patients with ≥mild MR and no class I indication of mitral valve surgery at baseline were retrospectively analyzed. The primary study end point was the composite of mitral valve surgery or death. During a mean follow-up of 5.4±3.2 years, there were 147 (53%) events: 96 (35%) MV surgeries and 66 (24%) deaths. Total LVEF and global longitudinal strain were not associated with the occurrence of events, whereas forward LVEF (
conclusionsThe results of this study suggest that the forward LVEF may be superior to the total LVEF and LV end-systolic diameter to predict outcomes in patients with primary MR. This simple and easily measurable parameter may be useful to improve risk stratification and select the best timing for intervention in patients with primary MR.
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