Evidence map›Paper›PMID 29079528›Full record

ArticleFree radical biology & medicine2017

Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.

Makan Golizeh, Kwangwon Lee, Serguei Ilchenko, Abdullah Ösme, James Bena, Rovshan G Sadygov, Sangeeta R Kashyap, Takhar Kasumov

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 58 citations in OpenAlex.

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  12. Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Makan GolizehDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Kwangwon LeeDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Serguei IlchenkoDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Abdullah ÖsmeDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
James BenaSection of Biostatistics, Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States.
Rovshan G SadygovDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, United States.
Sangeeta R KashyapDepartment of Endocrinology, Cleveland Clinic, Cleveland, OH, United States.
Takhar KasumovDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States; Department of Endocrinology, Cleveland Clinic, Cleveland, OH, United States. Electronic address: tkasumov@neomed.edu.
Northeast Ohio Medical University · USCleveland Clinic · USThe University of Texas Medical Branch at Galveston · US

Funding

Novel computational methods for in vivo proteome dynamics estimation using heavy water metabolic labeling and LC-MSR01GM112044 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SADYGOV, ROVSHAN G · 2015 to 2023
$2.7M
NIGMS NIH HHS R01 GM112044
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and oxidative modification of plasma proteins are known to occur under hyperglycemia and oxidative stress. In this study, shotgun proteomics and

Indexed as

Protein Processing, Post-TranslationalAdultAmino Acid SequenceCase-Control StudiesCeruloplasminDeuteriumDiabetes Mellitus, Type 2Diet, DiabeticFemaleGene Expression RegulationGlycated HemoglobinGlycosylationHumansIronIsotope LabelingMaleCeruloplasminDeuteriumGlycated Hemoglobinhemoglobin A1c protein, humanIronTransferrinCeruloplasminDeamidationHeavy water metabolic labelingHigh resolution mass spectrometryIron metabolismLC-MS/MSNon-enzymatic glycationOxidative stressProteome dynamicsSerotransferrinType 2 diabetes mellitus

Identifiers

PMID29079528
PMCPMC5739305
OpenAlexW2765282239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.