Evidence map›Paper›PMID 29079486›Full record

ArticleNeurotoxicology2018

Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination.

Carolyn Klocke, Joshua L Allen, Marissa Sobolewski, Jason L Blum, Judith T Zelikoff, Deborah A Cory-Slechta

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Air Pollution-Related Neurotoxicity Across the Life Span.Annual review of pharmacology and toxicology · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Fetotoxicity of Nanoparticles: Causes and Mechanisms.Nanomaterials (Basel, Switzerland) · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carolyn KlockeDepartment of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY, USA. Electronic address: carolyn_klocke@urmc.rochester.edu.
Joshua L AllenDepartment of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY, USA.
Marissa SobolewskiDepartment of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY, USA.
Jason L BlumDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA.
Judith T ZelikoffDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA.
Deborah A Cory-SlechtaDepartment of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY, USA.
University of Rochester · USNew York University · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
Developmental Exposures to Inhaled Air Pollution and the Autism Phenotype in MiceR01ES025541 · NIEHS · UNIVERSITY OF ROCHESTER · PI CORY-SLECHTA, DEBORAH A · 2015 to 2019
$2.2M
NIEHS NIH HHS P30 ES000260NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES025541NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

Accumulating studies indicate that the brain is a direct target of air pollution exposure during the fetal period. We have previously demonstrated that exposure to concentrated ambient particles (CAPs) during gestation produces ventriculomegaly, periventricular hypermyelination, and enlargement of the corpus callosum (CC) during postnatal development in mice. This study aimed to further characterize the cellular basis of the observed hypermyelination and determine if this outcome, among other effects, persisted as the brain matured. Analysis of CC-1

Indexed as

AnimalsCell DifferentiationCell ProliferationFemaleHydrocephalusMaleMiceMyelin SheathOligodendrogliaParticle SizeParticulate MatterPregnancyPrenatal Exposure Delayed EffectsSex FactorsParticulate MatterAir pollutionMyelinOligodendrocyteOligodendrocyte progenitor cellParticulate matter

Identifiers

PMID29079486
PMCPMC5857223
OpenAlexW2766427800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.