Evidence map›Paper›PMID 29079391›Full record

Trial reportContemporary clinical trials2018

Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial.

Amy M Pastva, Pamela W Duncan, Gordon R Reeves, M Benjamin Nelson, David J Whellan, Christopher M O'Connor, Joel D Eggebeen, Leigh Ann Hewston, Karen M Taylor, Robert J Mentz and 2 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Amy M PastvaDuke University School of Medicine, Durham, NC, USA. Electronic address: amy.pastva@duke.edu.
Pamela W DuncanWake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address: pduncan@wakehealth.edu.
Gordon R ReevesSidney Kimmel Medical College, Philadelphia, PA, USA. Electronic address: Gordon.Reeves@jefferson.edu.
M Benjamin NelsonWake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address: mbnelson@wakehealth.edu.
David J WhellanSidney Kimmel Medical College, Philadelphia, PA, USA. Electronic address: david.whellan@jefferson.edu.
Christopher M O'ConnorInova Heart and Vascular Institute, Falls Church, VA, USA. Electronic address: Christopher.oconner@inova.org.
Joel D EggebeenEmory University, Atlanta, GA, USA. Electronic address: joeleggebeen@gmail.com.
Leigh Ann HewstonThomas Jefferson University School of Health Professions, Philadelphia, PA, USA. Electronic address: Leigh.Hewston@jefferson.edu.
Karen M TaylorWake Forest Baptist Medical Center, Winston-Salem, NC, USA. Electronic address: kmtaylor@wakehealth.edu.
Robert J MentzDuke University School of Medicine, Durham, NC, USA. Electronic address: robert.mentz@duke.edu.
Paul B RosenbergDuke University School of Medicine, Durham, NC, USA. Electronic address: paul.b.rosenberg@duke.edu.
Dalane W KitzmanWake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address: dkitzman@wakehealth.edu.
Duke University · USWake Forest University · USSidney Kimmel Cancer Center · USAlaska Heart and Vascular Institute · USAtrium Health Wake Forest Baptist · USEmory University · USThomas Jefferson University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Heart Failure Clinical Research Network Regional Clinical Center (U10)U10HL110312 · NHLBI · DUKE UNIVERSITY · PI FELKER, GARY M · 2012 to 2018
$3.5M
NCATS NIH HHS UL1 TR001420NHLBI NIH HHS U10 HL110312NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG028716NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551
6 · The paper itself

Abstract

introductionAcute decompensated heart failure (ADHF) is the leading cause of hospitalization in older adults. Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial is a multi-site clinical trial to determine if physical rehabilitation intervention in older patients with ADHF improves physical function and reduces rehospitalizations. The REHAB-HF intervention aims to improve functional performance utilizing reproducible and progressive exercises that are individually tailored to the patient's physiological and physical capabilities. Fidelity of the intervention is essential to the trial's integrity and success. Maintaining fidelity is challenged by the complex, multi-domain design of the intervention implemented across multiple sites and delivered to an older, heterogeneous participant pool with severe underlying disease and multi-morbidity. METHODS/

designGiven the dynamic nature of the REHAB-HF intervention, rigorous fidelity strategies were formulated. In this paper we summarize the specific strategies that REHAB-HF is using to meet the National Institutes of Health (NIH) Behavior Change Consortium Treatment Fidelity Workgroup recommendations in 5 key areas: 1) ensuring the intervention dose is consistent across participants, 2) standardizing interventionist training, 3) monitoring intervention delivery, 4) evaluating participants' understanding of information provided, and 5) ensuring that participants use the skills taught in the intervention. DISCUSSION: Effective intervention fidelity strategies are essential to the reliability and validity of physical function intervention trials. The REHAB-HF trial has developed comprehensive, specific strategies to ensure intervention fidelity despite a challenging study population and a complex intervention to meet NIH recommendations. This experience provides a strong working model for future physical function intervention trials.

Indexed as

AgedAged, 80 and overDisability EvaluationExercise TherapyHeart FailureHumansMiddle AgedPhysical Therapy ModalitiesPostural BalanceQuality of LifeReproducibility of ResultsResearch DesignSingle-Blind MethodAcute decompensated heart failureAgingExerciseFidelityFrailtyRehabilitation

Identifiers

PMID29079391
PMCPMC5742023
OpenAlexW2766077638

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.