ArticleThe Journal of arthroplasty2018
Failure After Modern Total Knee Arthroplasty: A Prospective Study of 18,065 Knees.
Article in The Journal of arthroplasty, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Mean distraction force applied in tension-controlled ligament-balanced total knee arthroplasty: A systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Pooled it
- Robotic-assisted mechanically aligned total knee arthroplasty does not lead to better clinical and radiological outcomes when compared to conventional TKA: a systematic review and meta-analysis of randomized controlled trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Physical activity after revision knee arthroplasty including return to sport and work: a systematic review and meta-analysis including GRADE.BMC musculoskeletal disorders · 2023Pooled it
- Interventions for treating fractures of the distal femur in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Early complications and reoperation rates are similar amongst open reduction internal fixation, intramedullary nail, and distal femoral replacement for periprosthetic distal femur fractures: a systematic review and meta-analysis.Archives of orthopaedic and trauma surgery · 2021Pooled it
- Acquired Idiopathic Stiffness After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.The Journal of bone and joint surgery. American volume · 2019Pooled it
- Effect of virtual reality on perioperative anxiety, stress and pain in total hip arthroplasty: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Electrosprayed Chitosan-Calcium Phosphate Microshell Composite Coatings on Silanized Titanium Substrates.Journal of functional biomaterials · 2026Article
- Fast fix or false hope? Polyethylene exchange in unstable primary unconstrained total knee arthroplasty.Bone & joint open · 2026Article
- Full-flexion gap balancing-driven personalized preoperative planning for TKA: biomechanical evidence of improved load symmetry in an in vitro model.Arthroplasty (London, England) · 2026Article
- Nail-Plate Combination Fixation for Periprosthetic Distal Femoral Fractures Allows Early Weight-Bearing With Low Reoperation and Revision Rates.The Journal of arthroplasty · 2026Article
- Use of extended reality, virtual reality, augmented reality and mixed reality in clinical practice, education and research in knee arthroplasty: A scoping review.Journal of experimental orthopaedics · 2026Article
- Interlaboratory Reliability of Synovial Fluid Analysis in Prosthetic Knee Aspiration.Arthroplasty today · 2026Article
- Outcomes of locked plating and retrograde intramedullary nailing for periprosthetic distal femur fractures after TKA.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Advancements in Biomedical Sensors for Early Detection of Failure in Hip and Knee Implants: Scoping Review on Potential Sensors for Implant Integration.Annals of biomedical engineering · 2025Article
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- Are Changes in Physical Activity, Pain, and Quality of Life in Patients with Knee Osteoarthritis After Exercise Therapy and Education Beyond Normal Fluctuations? A Comparative Study.Journal of clinical medicine · 2025Article
- Robotic-assisted total knee arthroplasty reduced mid-term incidences of multiple orthopaedic complications: A large database study.Archives of orthopaedic and trauma surgery · 2025Article
- Predicting 30-day reoperation following primary total knee arthroplasty: machine learning model outperforms the ACS risk calculator.Medical & biological engineering & computing · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundWe sought is to determine the mechanism of failure among primary total knee arthroplasties (TKAs) performed at a single high-volume institution by asking the following research questions: (1) What are the most common failure modes for modern TKA designs? and (2) What are the preoperative risk factors for failure following primary TKA?
methodsFrom May 2007 to December 2012, 18,065 primary TKAs performed on 16,083 patients at a single institution were recorded in a prospective total joint arthroplasty registry with a minimum of 5-year follow-up. We retrospectively reviewed patient charts to determine a cause of failure for primary TKAs. A cox proportional hazard model was used to determine the risk of revision surgery following primary TKA.
resultsThe most common reasons for failure within 2 years after TKA were infection and stiffness. The multivariable regression identified the following preoperative risk factors for TKA failure: history of drug abuse (hazard ratio [HR] 4.68; P = 0.03), deformity/mechanical preoperative diagnosis (HR 3.52; P < .01), having a constrained condylar knee implant over posterior-stabilized implant (HR 1.99; P < .01), post-traumatic/trauma preoperative diagnosis (HR 1.78; P = .03), and younger age (HR 0.61; P < .01)
conclusionThese findings add to the growing data that primary TKAs are no longer failing from polyethylene wear-related issues. This study identified preoperative risk factors for failure of primary TKAs, which may be useful information for developing strategies to improve outcomes following TKA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.