Evidence map›Paper›PMID 29078392›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Exploitation of an iron transporter for bacterial protein antibiotic import.

Paul White, Amar Joshi, Patrice Rassam, Nicholas G Housden, Renata Kaminska, Jonathan D Goult, Christina Redfield, Laura C McCaughey, Daniel Walker, Shabaz Mohammed and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Advances in understanding Ton and Tol system motor proteins.Biochemical Society transactions · 2026
    Review
  3. Second-generation lysocins as therapeutics for treatingAntimicrobial agents and chemotherapy · 2025
    Article
  4. Review
  5. Article
  6. Article
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  10. Article
  11. Article
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  13. Article
  14. Tunable force transduction through theProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Paul WhiteDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Amar JoshiDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Patrice RassamDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Nicholas G HousdenDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Renata KaminskaDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Jonathan D GoultDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Christina RedfieldDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Laura C McCaugheyDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Daniel WalkerInstitute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Shabaz MohammedDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Colin KleanthousDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; colin.kleanthous@bioch.ox.ac.uk.ORCID 0000-0002-3273-0302
University of Oxford · GBUniversity of Glasgow · GBUniversity of Technology Sydney · AU

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Biotechnology and Biological Sciences Research Council BB/G020671/2NIDDK NIH HHS P30 DK089507Wellcome TrustWellcome Trust 201505/Z/16/Z
6 · The paper itself

Abstract

Unlike their descendants, mitochondria and plastids, bacteria do not have dedicated protein import systems. However, paradoxically, import of protein bacteriocins, the mechanisms of which are poorly understood, underpins competition among pathogenic and commensal bacteria alike. Here, using X-ray crystallography, isothermal titration calorimetry, confocal fluorescence microscopy, and in vivo photoactivatable cross-linking of stalled translocation intermediates, we demonstrate how the iron transporter FpvAI in the opportunistic pathogen

Indexed as

Anti-Bacterial AgentsBacterial Outer Membrane ProteinsBacteriocinsBiological TransportCrystallography, X-RayIronMembrane Transport ProteinsPeriplasmProtein TransportPseudomonas aeruginosaSiderophoresAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacteriocinsIronMembrane Transport ProteinsSiderophoresouter membrane receptorPseudomonas aeruginosapyocintransporter

Identifiers

PMID29078392
PMCPMC5692591
OpenAlexW2766328249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.