ArticleProceedings of the National Academy of Sciences of the United States of America2017
Organizing principles for the cerebral cortex network of commissural and association connections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed.
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Cortical similarity networks in the rat brain: Postnatal development and sensitivity to early life stress.Network neuroscience (Cambridge, Mass.) · 2026Article
- Intrinsic neuronal network organization of a mammalian peripheral nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The brain cortical similarity network: Development and sensitivity to early life stress in a rat model.bioRxiv : the preprint server for biology · 2025Article
- Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025Article
- Platinum Wire-Embedded Culturing Device for Interior Signal Recording from Lollipop-Shaped Neural Spheroids.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Knowledge mining of brain connectivity in massive literature based on transfer learning.Bioinformatics (Oxford, England) · 2024Article
- A new map of the rat isocortex and proisocortex: cytoarchitecture and MBrain structure & function · 2024Article
- Topographic organization of bidirectional connections between the cingulate region (infralimbic area and anterior cingulate area, dorsal part) and the interbrain (diencephalon) of the adult male rat.bioRxiv : the preprint server for biology · 2024Article
- Neural network architecture of a mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity.Nature communications · 2024Article
- Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity.Nature communications · 2024Article
- Impact of corpus callosum integrity on functional interhemispheric connectivity and cognition in healthy subjects.Brain imaging and behavior · 2024Article
- Article
- Network architecture of intrinsic connectivity in a mammalian spinal cord (the central nervous system's caudal sector).Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Intrinsic circuitry of the rhombicbrain (central nervous system's intermediate sector) in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Brain asymmetry is globally different in males and females: exploring cortical volume, area, thickness, and mean curvature.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Microglia complement signaling promotes neuronal elimination and normal brain functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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3 authors.
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Abstract
Cognition is supported by a network of axonal connections between gray matter regions within and between right and left cerebral cortex. Global organizing principles of this circuitry were examined with network analysis tools applied to monosynaptic association (within one side) and commissural (between sides) connections between all 77 cortical gray matter regions in each hemisphere of the rat brain. The analysis used 32,350 connection reports expertly collated from published pathway tracing experiments, and 5,394 connections of a possible 23,562 were identified, for a connection density of 23%-of which 20% (1,084) were commissural. Network community detection yielded a stable bihemispheric six-module solution, with an identical set in each hemisphere of three modules topographically forming a lateral core and medial shell arrangement of cortical regions. Functional correlations suggest the lateral module deals preferentially with environmental sensory-motor interactions and the ventromedial module deals preferentially with visceral control, affect, and short-term memory, whereas the dorsomedial module resembles the default mode network. Analysis of commissural connections revealed a set of unexpected rules to help generate hypotheses. Most notably, there is an order of magnitude more heterotopic than homotopic projections; all cortical regions send more association than commissural connections, and for each region, the latter are always a subset of the former; the number of association connections from each cortical region strongly correlates with the number of its commissural connections; and the module (dorsomedial) lying closest to the corpus callosum has the most complete set of commissural connections-and apparently the most complex function.
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