Evidence map›Paper›PMID 29078380›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

Qing He, Richard Bouley, Zun Liu, Marc N Wein, Yan Zhu, Jordan M Spatz, Chia-Yu Wang, Paola Divieti Pajevic, Antonius Plagge, Jodie L Babitt and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. MaternalFrontiers in genetics · 2021
    Article
  3. New and Old Osteocytic Cell Lines and 3D Models.Current osteoporosis reports · 2020
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Qing HeEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Richard BouleyProgram in Membrane Biology, Department of Medicine and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Zun LiuEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Marc N WeinEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Yan ZhuEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Jordan M SpatzEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Chia-Yu WangProgram in Membrane Biology, Department of Medicine and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Paola Divieti PajevicEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Antonius PlaggeDepartment of Cellular and Molecular Physiology, Institute of Translational Medicine University of Liverpool, Liverpool L69 3BX, United Kingdom.ORCID 0000-0001-6592-1343
Jodie L BabittProgram in Membrane Biology, Department of Medicine and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Murat BastepeEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; bastepe@helix.mgh.harvard.edu.
Harvard University · USBoston University · USUniversity of Liverpool · GB

Funding

TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Research BaseP30DK090868 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WELLING, PAUL A · 2010 to 2019
$11.1M
Cell Biology of Vasopressin-induced Water Channels-Research SupplementR01DK096586 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Dennis Brown · 2012 to 2026
$7.3M
Regulation of Iron Homeostasis by BMP SignalingR01DK087727 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L · 2010 to 2024
$6.0M
XLas Relative to Gsa in Bone and Mineral Ion MetabolismR01DK073911 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BASTEPE, MURAT · 2007 to 2020
$4.9M
Skeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DIVIETI PAJEVIC, PAOLA · 2014 to 2018
$3.5M
Dissecting the roles of class IIa HDACs in osteocyte biologyK08AR067285 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI WEIN, MARC NATHAN · 2015 to 2019
$698k
NIAMS NIH HHS K08 AR067285NIAMS NIH HHS P30 AR066261NIDDK NIH HHS P30 DK090868NIDDK NIH HHS R01 DK073911NIDDK NIH HHS R01 DK087727NIDDK NIH HHS R01 DK096586NIDDK NIH HHS T32 DK007028
6 · The paper itself

Abstract

Alterations in the activity/levels of the extralarge G protein α-subunit (XLαs) are implicated in various human disorders, such as perinatal growth retardation. Encoded by

Indexed as

AnimalsCell LineClathrinCRISPR-Cas SystemsEndocytosisGTP-Binding Protein alpha SubunitsHeartHEK293 CellsHumansIronMiceMice, KnockoutMuscle, SkeletalOsteocytesProteomicsReceptors, VasopressinClathrinGTP-Binding Protein alpha SubunitsIronReceptors, VasopressinSorting NexinsTransferrinendocytosisGNASheterotrimeric G proteinsstimulatory G proteintransferrin

Identifiers

PMID29078380
PMCPMC5692581
OpenAlexW2766802016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.