Evidence map›Paper›PMID 29078358›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of

Usheer Kanjee, Christof Grüring, Mudit Chaand, Kai-Min Lin, Elizabeth Egan, Jale Manzo, Patrick L Jones, Tiffany Yu, Robert Barker, Michael P Weekes and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 63 citations in OpenAlex.

  1. Impact ofCurrent research in parasitology & vector-borne diseases · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Applications of CRISPR in Parasitology.Current pharmaceutical biotechnology · 2025
    Review
  7. The reticulocyte restriction: invasion ligand RBP1a ofFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. The Cellular and Molecular Interaction Between Erythrocytes andFrontiers in cellular and infection microbiology · 2022
    Review
  18. Review
  19. Review
  20. Plasmodium vivax Strains Use Alternative Pathways for Invasion.The Journal of infectious diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Usheer KanjeeDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.ORCID 0000-0002-3169-4557
Christof GrüringDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Mudit ChaandDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Kai-Min LinCambridge Institute for Medical Research, Cambridge, CB2 OXY, United Kingdom.ORCID 0000-0003-2109-1530
Elizabeth EganDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Jale ManzoDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Patrick L JonesSanofi-Genzyme, Waltham, MA 02451.
Tiffany YuDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Robert BarkerSanofi-Genzyme, Waltham, MA 02451.
Michael P WeekesCambridge Institute for Medical Research, Cambridge, CB2 OXY, United Kingdom.
Manoj T DuraisinghDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115; mduraisi@hsph.harvard.edu.
Harvard University · USNational Institute for Health Research · GB

Funding

Functional analysis of red blood cell determinants of Plasmodium invasionR01HL139337 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2017 to 2020
$2.3M
Functional analysis of erythrocyte determinants of malaria infectionR01AI091787 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2011 to 2015
$2.0M
CIHRNHLBI NIH HHS R01 HL139337NIAID NIH HHS R01 AI091787Wellcome TrustWellcome Trust 108070/Z/15/Z
6 · The paper itself

Abstract

During malaria blood-stage infections,

Indexed as

Antigens, ProtozoanBasiginCarrier ProteinsCell DifferentiationCell Line, TumorClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsEpigenesis, GeneticErythrocytesGene Knockout TechniquesHematopoietic Stem CellsHost-Parasite InteractionsHumansHyaluronan ReceptorsK562 CellsLeukemia, Erythroblastic, AcuteAntigens, ProtozoanBasiginCarrier ProteinsHyaluronan ReceptorsLigandsProtozoan ProteinsRH5 protein, Plasmodium falciparumBSGCD44CRISPR/Cas9parasite invasionPlasmodium falciparum

Identifiers

PMID29078358
PMCPMC5676921
OpenAlexW2765332035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.