Evidence map›Paper›PMID 29078354›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Enhanced antibacterial activity through the controlled alignment of graphene oxide nanosheets.

Xinglin Lu, Xunda Feng, Jay R Werber, Chiheng Chu, Ines Zucker, Jae-Hong Kim, Chinedum O Osuji, Menachem Elimelech

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Review
  2. Article
  3. [Research progress of electroactivity graphene-based materials in bone repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Safety Assessment of Graphene-Based Materials.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Bacterial eliminationChemical science · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Adhesion preference of the sticky bacteriumFrontiers in bioengineering and biotechnology · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinglin LuDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.
Xunda FengDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.
Jay R WerberDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.
Chiheng ChuDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.
Ines ZuckerDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.
Jae-Hong KimDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.
Chinedum O OsujiDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286.ORCID 0000-0003-0261-3065
Menachem ElimelechDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06520-8286 menachem.elimelech@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cytotoxicity of 2D graphene-based nanomaterials (GBNs) is highly important for engineered applications and environmental health. However, the isotropic orientation of GBNs, most notably graphene oxide (GO), in previous experimental studies obscured the interpretation of cytotoxic contributions of nanosheet edges. Here, we investigate the orientation-dependent interaction of GBNs with bacteria using GO composite films. To produce the films, GO nanosheets are aligned in a magnetic field, immobilized by cross-linking of the surrounding matrix, and exposed on the surface through oxidative etching. Characterization by small-angle X-ray scattering and atomic force microscopy confirms that GO nanosheets align progressively well with increasing magnetic field strength and that the alignment is effectively preserved by cross-linking. When contacted with the model bacterium

Indexed as

Anti-Bacterial AgentsCell MembraneCoated Materials, BiocompatibleElectron TransportEscherichia coliGlutathioneGraphiteImmobilizationMagnetic FieldsMicroscopy, Atomic ForceNanostructuresOxidation-ReductionOxidesReactive Oxygen SpeciesAnti-Bacterial AgentsCoated Materials, BiocompatibleGlutathioneGraphiteOxidesReactive Oxygen Speciescytotoxicity mechanismedge-mediated effectenhanced antibacterial activitygraphene oxidemagnetic alignment

Identifiers

PMID29078354
PMCPMC5699062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.