ArticleProceedings of the National Academy of Sciences of the United States of America2017
Hedgehog signaling regulates ciliary localization of mouse odorant receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Disproportionality analysis comparing safety profiles of sonidegib and vismodegib based on the FAERS database.Scientific reports · 2025Article
- Constancy of olfactory cilia in rodents.Chemical senses · 2025Article
- Expression and Functional Analysis of the Smo Protein inInsects · 2024Article
- A Pilot Immunohistochemical Study Identifies Hedgehog Pathway Expression in Sinonasal Adenocarcinoma.International journal of molecular sciences · 2024Article
- The Role of Hedgehog Signaling in the Melanoma Tumor Bone Microenvironment.International journal of molecular sciences · 2023Article
- Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila.Nature communications · 2022Article
- A multivesicular body-like organelle mediates stimulus-regulated trafficking of olfactory ciliary transduction proteins.Nature communications · 2022Article
- Mir-326 potentiates radiosensitivity of cervical squamous cell carcinoma through downregulating SMO expression in the Hedgehog signaling pathway.Genes & genomics · 2022Article
- INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons.Journal of cell science · 2022Article
- Cilia signaling and obesity.Seminars in cell & developmental biology · 2021Review
- Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus.Molecular brain · 2019Article
- Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures.Frontiers in cellular neuroscience · 2019Article
- Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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3 authors at 1 institution in 1 country.
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Abstract
The ciliary localization of odorant receptors (ORs) is evolutionary conserved and essential for olfactory transduction. However, how the transport of ORs is regulated in mammalian olfactory sensory neurons is poorly understood. Here we demonstrate that odorant responsiveness and OR transport is regulated by the Hedgehog pathway. OR transport is inhibited by conditional gene inactivation of the Hedgehog signal mediator Smoothened (Smo) as well as by systemic administration of the Smo inhibitor vismodegib, a clinically used anticancer drug reported to distort smell perception in patients. The ciliary phenotype of Smo inhibition is haploinsufficient, cell autonomous, and correlates with the accumulation of OR-containing putative transport vesicles in the cytosol. The Smo-dependent OR transport route works in parallel with a low basal transport of vesicle containing both ORs and other olfactory transduction components. These findings both define a physiological function of Hedgehog signaling in olfaction and provide an important evolutionary link between olfaction and the requirement of a ciliary compartment for Hedgehog signaling.
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