ArticleProceedings of the National Academy of Sciences of the United States of America2017
Widespread covariation of early environmental exposures and trait-associated polygenic variation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.Behavior genetics · 2019Pooled it
- A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry.Human molecular genetics · 2018Pooled it
- Prenatal famine exposure restricts genetic effects on birth weight with implications for metabolic disease risk.Communications medicine · 2026Article
- Evocative effects of children's education-associated genetics on maternal parenting: results from the Norwegian mother, father and child cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Polygenic scores for depression are associated with indices of neighborhood adversity.Journal of psychopathology and clinical science · 2025Article
- Do Children Cause the Cognitive Stimulation they Receive? Modelling the Direction of Causality.Behavior genetics · 2024Article
- A genetically informed Registered Report on adverse childhood experiences and mental health.Nature human behaviour · 2023Article
- Observational
- Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development.Frontiers in psychiatry · 2023Article
- The next 10 years of behavioural genomic research.JCPP advances · 2022Article
- Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
- Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene-environment correlations.Journal of psychopathology and clinical science · 2022Article
- Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults.Translational psychiatry · 2022Article
- Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene-environment correlation.European child & adolescent psychiatry · 2022Article
- Causal Inference with Genetic Data: Past, Present, and Future.Cold Spring Harbor perspectives in medicine · 2022Review
- Genetic Risk of Cardiovascular Disease Is Associated with Macular Ganglion Cell-Inner Plexiform Layer Thinning in an Early Glaucoma Cohort.Ophthalmology science · 2022Article
- Life history trade-offs associated with exposure to low maternal capital are different in sons compared to daughters: Evidence from a prospective Brazilian birth cohort.Frontiers in public health · 2022Article
- From Genome-Wide to Environment-Wide: Capturing the Environome.Perspectives on psychological science : a journal of the Association for Psychological Science · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Although gene-environment correlation is recognized and investigated by family studies and recently by SNP-heritability studies, the possibility that genetic effects on traits capture environmental risk factors or protective factors has been neglected by polygenic prediction models. We investigated covariation between trait-associated polygenic variation identified by genome-wide association studies (GWASs) and specific environmental exposures, controlling for overall genetic relatedness using a genomic relatedness matrix restricted maximum-likelihood model. In a UK-representative sample (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.