Evidence map›Paper›PMID 29078276›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

Takouhie Mgrditchian, Tsolere Arakelian, Jérôme Paggetti, Muhammad Zaeem Noman, Elodie Viry, Etienne Moussay, Kris Van Moer, Stephanie Kreis, Coralie Guerin, Stephanie Buart and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 218 citations in OpenAlex.

  1. Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Autophagy in Melanoma: Molecular Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
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  17. Article
  18. Jun, an Oncological Foe or Friend?International journal of molecular sciences · 2025
    Review
  19. Review
  20. Review

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Takouhie MgrditchianLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Tsolere ArakelianLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Jérôme PaggettiLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Muhammad Zaeem NomanLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Elodie ViryLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Etienne MoussayLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Kris Van MoerLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Stephanie KreisLife Sciences Research Unit, University of Luxembourg, L-4367 Belvaux, Luxembourg.
Coralie GuerinNational Cytometry Platform, Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg.
Stephanie BuartINSERM UMR 1186, Gustave Roussy Cancer Center, 94805-Villejuif, France.
Caroline RobertINSERM UMR 981, Gustave Roussy Cancer Center, 94805-Villejuif, France.
Christophe BorgDepartment of Medical Oncology, University Hospital of Besançon, 25000 Besançon, France.
Philippe VielhLaboratoire National de Santé, L-3555 Dudelange, Luxembourg.
Salem ChouaibINSERM UMR 1186, Gustave Roussy Cancer Center, 94805-Villejuif, France.
Guy BerchemLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.
Bassam JanjiLaboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg; bassam.janji@lih.lu.
Luxembourg Institute of Health · LUInstitut Gustave Roussy · FRCentre Hospitalier Universitaire de Besançon · FRInserm · FRLaboratoire National de Santé · LUUniversity of Luxembourg · LU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While blocking tumor growth by targeting autophagy is well established, its role on the infiltration of natural killer (NK) cells into tumors remains unknown. Here, we investigate the impact of targeting autophagy gene Beclin1 (

Indexed as

AnimalsAutophagyBeclin-1Cell Line, TumorChemokine CCL5HumansImmunotherapyKiller Cells, NaturalMelanomaMiceMice, Inbred C57BLNatural Cytotoxicity Triggering Receptor 1Beclin-1Chemokine CCL5Natural Cytotoxicity Triggering Receptor 1autophagyCCL5immunotherapymelanomanatural killer

Identifiers

PMID29078276
PMCPMC5676879
OpenAlexW2766463091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.