Evidence map›Paper›PMID 29078028›Full record

ArticleInfluenza and other respiratory viruses2018

Respiratory syncytial virus evaluation among asymptomatic and symptomatic subjects in a university hospital in Sao Paulo, Brazil, in the period of 2009-2013.

Luciana Peniche Moreira, Aripuana Sakurada Aranha Watanabe, Clarice Neves Camargo, Thais Boim Melchior, Celso Granato, Nancy Bellei

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019
    Trial
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  12. Review
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  15. Who should be prioritised for COVID-19 vaccination?Human vaccines & immunotherapeutics · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. The Risk of Treating Populations Instead of Patients.CPT: pharmacometrics & systems pharmacology · 2019
    Article
  20. The molecular epidemiology of respiratory viruses in military trainees in Iran.Medical journal of the Islamic Republic of Iran · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Luciana Peniche MoreiraMedicine Department, Sao Paulo Federal University, Sao Paulo, Brazil.
Aripuana Sakurada Aranha WatanabeMedicine Department, Sao Paulo Federal University, Sao Paulo, Brazil.ORCID 0000-0001-9445-3833
Clarice Neves CamargoMedicine Department, Sao Paulo Federal University, Sao Paulo, Brazil.
Thais Boim MelchiorMedicine Department, Sao Paulo Federal University, Sao Paulo, Brazil.
Celso GranatoMedicine Department, Sao Paulo Federal University, Sao Paulo, Brazil.
Nancy BelleiMedicine Department, Sao Paulo Federal University, Sao Paulo, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe respiratory syncytial virus (RSV) is recognized as an important cause of respiratory tract infections. Immunocompromised patients, healthcare workers (HCWs) and children contacts are at increased risk of acquiring the infection. However, the impact of asymptomatic infection in transmission has not been well studied.

objectivesthis study evaluated the frequency and viral load (VL) of RSV in nasal swab samples of individuals with different risk factors for acquiring infection in a university hospital in Sao Paulo, Brazil.

methodsWe included 196 symptomatic children and their 192 asymptomatic caregivers, 70 symptomatic and 95 asymptomatic HCWs, 43 samples from symptomatic HIV-positive outpatients, and 100 samples of asymptomatic HIV patients in the period of 2009-2013.

resultsRSV infection was detected in 10.1% (70/696) of samples, 4.4% (17/387) of asymptomatic patients, and 17.1% (53/309) from symptomatic patients. (P < .0001). The VL of symptomatic patients (4.7 log copies/mL) was significantly higher compared to asymptomatic patients (2.3 log copies/mL). RSV detection among asymptomatic caregivers (6.8%; 13/192) was significantly higher compared to other asymptomatic adults, HIV and HCWs (2.0%; 4/195; P = .0252). A close contact with an infected child at home was an important risk to RSV acquisition [OR 22.6 (95% CI 4.8-106.7)]. Children who possibly transmitted the virus to their asymptomatic contacts had significantly higher viral load than children who probably did not transmit (P < .0001).

conclusionsAccording to our results, it is important to know if people circulating inside the hospital have close contact with acute respiratory infected children.

Indexed as

Hospitals, UniversityViral LoadAdultAsymptomatic InfectionsBrazilCaregiversChildChild, PreschoolFemaleHealth PersonnelHumansInfantMaleMiddle AgedNoseReal-Time Polymerase Chain Reactionasymptomaticrespiratory syncytial virussymptomaticviral load

Identifiers

PMID29078028
PMCPMC5907818
OpenAlexW2766648230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.