ArticleSchizophrenia bulletin2018
Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06382532 (Biological Diagnostic Techniques for the Diagnosis of Depressive Disorders Malinger Based on the Niacin Skin Response Test), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biological Diagnostic Techniques for the Diagnosis of Depressive Disorders Malinger Based on the Niacin Skin Response Test (NSRT)
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Blunted Niacin Skin Flushing Response in Schizophrenia: A Meta-analysis.Schizophrenia bulletin · 2026Pooled it
- Blunted Niacin Skin Flushing Response in Mood Disorders: A Meta-Analysis of Case-Control Studies.Depression and anxiety · 2026Pooled it
- Clinical application of niacin-induced skin flush response in adolescents with psychiatric disorders and its correlation with clinical blood test indicators.BMC psychiatry · 2026Article
- The interplay of niacin skin flush response with plasma MDA, TNOS, iNOS and clinical symptom severity in chronic schizophrenia.BMC psychiatry · 2026Article
- Blunted niacin skin flushing response with subtype-specific clinical associations in adolescent bipolar disorder.BMC psychiatry · 2026Article
- Differentiation of psychotic and affective disorder patients from healthy controls using the niacin skin flush test: a novel analytical method and the SKINREMS system-preliminary research.Scientific reports · 2026Article
- Exploring niacin skin flushing response in psychological screening of college students.BMC psychology · 2026Article
- Correlations of oxidative stress markers with niacin sensitivity in male patients with chronic schizophrenia.BMC psychiatry · 2025Article
- Screening for individuals with postpartum depression by an attenuated and delayed niacin skin flushing response: a case control study.BMC pregnancy and childbirth · 2025Article
- An open dataset and machine learning algorithms for Niacin Skin-Flushing Response based screening of psychiatric disorders.BMC psychiatry · 2025Article
- Cognitive impairments in first-episode psychosis patients with attenuated niacin response.Schizophrenia research. Cognition · 2025Article
- Efficacy of identifying Treatment-Resistant and non-Treatment-Resistant Schizophrenia using niacin skin flushing response combined with clinical feature.Schizophrenia (Heidelberg, Germany) · 2025Article
- Potential of niacin skin flush response in adolescent depression identification and severity assessment: a case-control study.BMC psychiatry · 2024Article
- Attenuated niacin response is associated with a subtype of first-episode drug-naïve psychosis characterized as serious negative symptoms.European archives of psychiatry and clinical neuroscience · 2023Article
- Diagnostic value of niacin skin blunting response in adolescent patients with depression.BMC psychiatry · 2023Article
- Niacin Skin Flush Backs-From the Roots of the Test to Nowadays Hope.Journal of clinical medicine · 2023Review
- Niacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship.Schizophrenia (Heidelberg, Germany) · 2022Article
- Attenuated niacin-induced skin flush response in individuals with clinical high risk for psychosis.General psychiatry · 2022Article
- Shared Biological Pathways between Antipsychotics and Omega-3 Fatty Acids: A Key Feature for Schizophrenia Preventive Treatment?International journal of molecular sciences · 2021Review
- Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia.EBioMedicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, to identify a subgroup of the patients with homogeneous biochemical traits will provide a new angle for both researchers and clinicians to understand and manage the disease. In this study, we employed the niacin skin-flushing test in Chinese population and confirmed a niacin-blunted subgroup of SZ patients distinguishable from mood disorders (MD) and normal individuals. This subgroup accounted for 30.67% of the total SZ patients with a specificity of 88.37% in male subjects and 83.75% in female subjects. We support the notion that bluntness in niacin skin test might reflect abnormalities in membrane fatty acid composition, which could be induced by increased PLA2 enzyme activity, in vivo oxidative stress or lipid metabolism imbalance in SZ. Further studies are encouraged to clarify the molecular origins of niacin-bluntness in SZ, which would provide extra clues for etiological research in schizophrenia and for new targeted treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.