Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed.

1. Quantitative Systems Toxicology Predicts Ivacaftor-Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity.Clinical pharmacology and therapeutics · 2026
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2. Evaluation of Elexacaftor/Tezacaftor/Ivacaftor-Mediated Drug-Induced Liver Injury Using a Liver-On-Chip Model.Clinical and translational science · 2025
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3. Cell-based approaches for the mechanistic understanding of drug-induced cholestatic liver injury.Archives of toxicology · 2025
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4. Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques.Cell & bioscience · 2024
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5. Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures.Journal of hazardous materials · 2024
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6. Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2024
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7. Liver three-dimensional cellular models for high-throughput chemical testing.Cell reports methods · 2023
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8. In Vitro Models for Studying Chronic Drug-Induced Liver Injury.International journal of molecular sciences · 2022
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9. Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022
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10. Computational toxicology (Amsterdam, Netherlands) · 2021
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11. 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.Clinical and translational science · 2021
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12. Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury.Toxicology in vitro : an international journal published in association with BIBRA · 2021
    Article
13. Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
14. The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development.Archives of toxicology · 2020
    Review
15. Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Article
16. 3D-bioprinted HepaRG cultures as a model for testing long term aflatoxin B1 toxicityToxicology reports · 2020
    Article
17. Improving natural product research translation: From source to clinical trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
18. Next generation sequencing data for use in risk assessment.Current opinion in toxicology · 2019
    Article
19. Advanced In Vitro HepaRG Culture Systems for Xenobiotic Metabolism and Toxicity Characterization.European journal of drug metabolism and pharmacokinetics · 2019
    Review
20. Targeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model.Journal of biological engineering · 2019
    Article

Corrections and comments

• Erratum for
  From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.2017

Authors and funding

6 authors.

Funding

Abstract

PubMed holds no abstract for this paper.