ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018
Association of serum magnesium with all-cause mortality in patients with and without chronic kidney disease in the Dallas Heart Study.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.Journal of nephrology · 2019Pooled it
- Association between dietary magnesium intake and all-cause mortality in patients with chronic kidney disease: Insights from NHANES 1999-2018.Clinical medicine (London, England) · 2026Article
- Serum Magnesium Concentrations in the United States-An Updated Population Reference Interval in Children and Adults.The Journal of nutrition · 2026Article
- Efficacy of finerenone in reducing proteinuria in diabetic kidney disease with maximum tolerable doses of dapagliflozin and telmisartan.World journal of nephrology · 2026Article
- Magnesium Balance in Chronic Kidney Disease: Mineral Metabolism, Immunosuppressive Therapies and Sodium-Glucose Cotransporter 2 Inhibitors.International journal of molecular sciences · 2025Review
- Relationship between magnesium intake and decline in kidney function, incident chronic kidney disease and incident cardiovascular disease.Clinical kidney journal · 2025Article
- Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.Clinical kidney journal · 2025Article
- Magnesium depletion scores as a risk factor for prevalence and mortality rates of urinary incontinence: a national survey analysis.Frontiers in nutrition · 2025Article
- Association between magnesium, erythropoietin resistance and mortality: the Japanese Dialysis Outcomes and Practice Patterns Study (J-DOPPS).Clinical kidney journal · 2024Article
- Review
- Ionized and total magnesium levels in patients with chronic kidney disease: associated factors and outcomes.Clinical kidney journal · 2024Article
- Article
- Serum Magnesium Levels and Cardiovascular Outcomes in Systolic Blood Pressure Intervention Trial Participants.Kidney medicine · 2023Article
- Magnesium in Kidney Function and Disease-Implications for Aging and Sex-A Narrative Review.Nutrients · 2023Review
- Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases.Nutrients · 2022Article
- Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients.Nutrients · 2022Article
- Magnesium-A More Important Role in CKD-MBD than We Thought.Diagnostics (Basel, Switzerland) · 2022Review
- Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.Kidney medicine · 2022Article
- The association between use of proton-pump inhibitors and excess mortality after kidney transplantation: A cohort study.PLoS medicine · 2020Observational
- Serum magnesium, mortality and disease progression in chronic kidney disease.BMC nephrology · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Low serum magnesium (SMg) has been linked to increased mortality and cardiovascular disease (CVD) in the general population. We examined whether this association is similar in participants with versus without prevalent chronic kidney disease (CKD) in the multiethnic Dallas Heart Study (DHS) cohort. Methods: SMg was analyzed as a continuous variable and divided into tertiles. Study outcomes were all-cause death, cardiovascular (CV) death or event, and CVD surrogate markers, evaluated using multivariable Cox regression models adjusted for demographics, comorbidity, anthropometric and biochemical parameters including albumin, phosphorus and parathyroid hormone, and diuretic use. Median follow-up was 12.3 years (11.9-12.8, 25th percentile-75th percentile). Results: Among 3551 participants, 306 (8.6%) had prevalent CKD. Mean SMg was 2.08 ± 0.19 mg/dL (0.85 ± 0.08 mM, mean ± SD) in the CKD and 2.07 ± 0.18 mg/dL (0.85 ± 0.07 mM) in the non-CKD subgroups. During the follow-up period, 329 all-cause deaths and 306 CV deaths or events occurred. In a fully adjusted model, every 0.2 mg/dL decrease in SMg was associated with ∼20-40% increased hazard for all-cause death in both CKD and non-CKD subgroups. In CKD participants, the lowest SMg tertile was also independently associated with all-cause death (adjusted hazard ratio 2.31; 95% confidence interval 1.23-4.36 versus 1.15; 0.55-2.41; for low versus high tertile, respectively). Conclusions: Low SMg levels (1.4-1.9 mg/dL; 0.58-0.78 mM) were independently associated with all-cause death in patients with prevalent CKD in the DHS cohort. Randomized clinical trials are important to determine whether Mg supplementation affects survival in CKD patients.
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