ReviewPain medicine (Malden, Mass.)2018
From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain.
Review in Pain medicine (Malden, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Exploring the Relationship Between Different Pain Patterns and Depressive Symptom Among Older Koreans: Using Latent Growth Model.Psychiatry investigation · 2025Article
- Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception.Nature communications · 2024Article
- Patient Experiences and Challenges in the Management of Autoinflammatory Diseases-Data from the International FMF & AID Global Association Survey.Journal of clinical medicine · 2024Article
- Pain relief and associated factors: a cross-sectional observational web-based study in a Quebec cohort of persons living with chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn.The Journal of comparative neurology · 2023Article
- BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges.Brain and behavior · 2023Review
- RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain.Brain : a journal of neurology · 2023Article
- Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics.Frontiers in microbiology · 2023Article
- Objective evidence for chronic back pain relief by Medical Yoga therapy.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- The Persistent Pain Transcriptome: Identification of Cells and Molecules Activated by Hyperalgesia.The journal of pain · 2021Article
- A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets.Science signaling · 2021Article
- Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain.Pharmacological reviews · 2021Review
- eIF4E phosphorylation modulates pain and neuroinflammation in the aged.GeroScience · 2020Article
- ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain.International journal of molecular sciences · 2020Review
- Article
- MNK-eIF4E signalling is a highly conserved mechanism for sensory neuron axonal plasticity: evidence fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation.Acta neuropathologica communications · 2019Article
- Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain.Theranostics · 2019Article
- Relationship between concealment of emotions at work and musculoskeletal symptoms: results from the third Korean working conditions survey.Industrial health · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Objective: Persistent pain causes untold misery worldwide and is a leading cause of disability. Despite its astonishing prevalence, pain is undertreated, at least in part because existing therapeutics are ineffective or cause intolerable side effects. In this review, we cover new findings about the neurobiology of pain and argue that all but the most transient forms of pain needed to avoid tissue damage should be approached as a disease where a cure can be the goal of all treatment plans, even if attaining this goal is not yet always possible. Design: We reviewed the literature to highlight recent advances in the area of the neurobiology of pain. Results: We discuss barriers that are currently hindering the achievement of this goal, as well as the development of new therapeutic strategies. We also discuss innovations in the field that are creating new opportunities to treat and even reverse persistent pain, some of which are in late-phase clinical trials. Conclusion: We conclude that the confluence of new basic science discoveries and development of new technologies are creating a path toward pain therapeutics that should offer significant hope of a cure for patients and practitioners alike. Classification of Evidence. Our review points to new areas of inquiry for the pain field to advance the goal of developing new therapeutics to treat chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.