Evidence map›Paper›PMID 29077507›Full record

SynthesisAmerican journal of respiratory cell and molecular biology2018

Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.

Han Chen, Brian E Cade, Kevin J Gleason, Andrew C Bjonnes, Adrienne M Stilp, Tamar Sofer, Matthew P Conomos, Sonia Ancoli-Israel, Raanan Arens, Ali Azarbarzin and 52 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  15. Review
  16. Article
  17. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

62 authors at 20 institutions in 7 countries.

Han Chen1 Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-9510-4923
Brian E Cade4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Kevin J Gleason4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Andrew C Bjonnes7 Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts.
Adrienne M Stilp9 Department of Biostatistics, University of Washington, Seattle, Washington.
Tamar Sofer4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Matthew P Conomos9 Department of Biostatistics, University of Washington, Seattle, Washington.
Sonia Ancoli-Israel10 Departments of Medicine and Psychiatry, University of California, San Diego, California.
Raanan Arens11 the Children's Hospital at Montefiore, Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine, Bronx, New York.
Ali Azarbarzin4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Graeme I Bell12 Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, the University of Chicago, Chicago, Illinois.
Jennifer E Below2 Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health and.
Sung Chun7 Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts.
Daniel S Evans15 California Pacific Medical Center Research Institute, San Francisco, California.
Ralf Ewert16 Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Alexis C Frazier-Wood17 Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas.
Sina A Gharib18 Computational Medicine Core, Center for Lung Biology, University of Washington Medicine Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
José Haba-Rubio19 Center of Investigation and Research on Sleep, Lausanne University Hospital, Lausanne, Switzerland.
Erika W Hagen20 Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin.
Raphael Heinzer19 Center of Investigation and Research on Sleep, Lausanne University Hospital, Lausanne, Switzerland.
David R Hillman21 Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
W Craig Johnson9 Department of Biostatistics, University of Washington, Seattle, Washington.
Zoltan Kutalik22 Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
Jacqueline M Lane4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Emma K Larkin25 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee.
Seung Ku Lee26 Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Jeokgum-ro, Danwon-gu, Ansan-si, Gyeonggi-Do, Republic of Korea.
Jingjing Liang27 Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Jose S Loredo28 Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California.
Sutapa Mukherjee29 Adelaide Institute for Sleep Health, Flinders Centre of Research Excellence, Flinders University, Adelaide, South Australia, Australia.
Lyle J Palmer30 School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
George J Papanicolaou31 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Thomas Penzel32 University Hospital Charité Berlin, Sleep Center, Berlin, Germany.
Paul E Peppard20 Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin.
Wendy S Post33 Division of Cardiology, Johns Hopkins University, Baltimore, Maryland.
Alberto R Ramos34 Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
Ken Rice9 Department of Biostatistics, University of Washington, Seattle, Washington.
Jerome I Rotter35 Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics at Harbor-University of California Los Angeles Medical Center, Torrance, California.
Scott A Sands4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Neomi A Shah36 Division of Pulmonary, Critical Care, and Sleep, Icahn School of Medicine at Mount Sinai, New York, New York.
Chol Shin37 Department of Pulmonary, Sleep, and Critical Care Medicine, College of Medicine, Korea University Ansan Hospital, Jeokgum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Republic of Korea.
Katie L Stone15 California Pacific Medical Center Research Institute, San Francisco, California.
Beate Stubbe16 Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Jae Hoon Sul7 Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts.
Mehdi Tafti19 Center of Investigation and Research on Sleep, Lausanne University Hospital, Lausanne, Switzerland.
Kent D Taylor35 Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics at Harbor-University of California Los Angeles Medical Center, Torrance, California.
Alexander Teumer40 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Timothy A Thornton9 Department of Biostatistics, University of Washington, Seattle, Washington.
Gregory J Tranah15 California Pacific Medical Center Research Institute, San Francisco, California.
Chaolong Wang1 Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Heming Wang4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Simon C Warby42 Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada.
D Andrew Wellman4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Phyllis C Zee43 Department of Neurology and Sleep Medicine Center, Northwestern University, Chicago, Illinois.
Craig L Hanis2 Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health and.
Cathy C Laurie9 Department of Biostatistics, University of Washington, Seattle, Washington.
Daniel J Gottlieb4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Sanjay R Patel45 Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Xiaofeng Zhu27 Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Shamil R Sunyaev7 Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts.
Richa Saxena4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Xihong Lin1 Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Susan Redline4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Brigham and Women's Hospital · USUniversity of Washington · USBroad Institute · USCalifornia Pacific Medical Center · USHarvard University · USUniversitätsmedizin Greifswald · DEUniversity of Lausanne · CHCase Western Reserve University · USCenter for Human Genetics · USKorea University · KRUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of Wisconsin–Madison · USAlbert Einstein College of Medicine · USCharité - Universitätsmedizin Berlin · DEChildren's Nutrition Research Center at Baylor College of Medicine · USFlinders University · AUIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USNational Heart Lung and Blood Institute · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
EPIDEMIOLOGY OF SLEEP-DISORDERED BREATHING IN ADULTSR01HL062252 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PEPPARD, PAUL E · 1999 to 2013
$14.1M
Vascular Effects of Heparan Sulfate ProteoglycansP50HL056984 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALL, ALAN RICHARD · 1997 to 2006
$13.1M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
NCATS NIH HHS KL2 TR000461NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001881NCI NIH HHS P01 CA134294NCI NIH HHS R35 CA197449NCRR NIH HHS KL2 RR024990NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K01 HL135405NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS P50 HL056984NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL062252NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL102830NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R35 HL135818NHLBI NIH HHS T32 HL007901NHLBI NIH HHS U01 HL053941NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIAID NIH HHS R01 AI085014NIAMS NIH HHS R01 AR051124NIAMS NIH HHS RC2 AR058973NIAMS NIH HHS U01 AR066160NIA NIH HHS R01 AG023629NIA NIH HHS R21 AG056952NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK073541NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859NIDDK NIH HHS U01 DK085501
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups, and a large proportion of the heritability remains unexplained. The apnea-hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Because OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multiethnic samples. We performed genome-wide association tests for up to 19,733 participants of African, Asian, European, and Hispanic/Latino American ancestry in 7 studies. We identified rs12936587 on chromosome 17 as a possible quantitative trait locus for NREM AHI in men (N = 6,737; P = 1.7 × 10

Indexed as

Genome-Wide Association StudyAdultAgedFemaleHumansMaleMiddle AgedPhosphatidylethanolamine N-MethyltransferaseQuantitative Trait Lociras ProteinsSex CharacteristicsSleep Apnea, ObstructiveSleep, REMSterol Regulatory Element Binding Protein 1Trans-ActivatorsTranscription FactorsPEMT protein, humanPhosphatidylethanolamine N-MethyltransferaseRAI1 protein, humanRASD1 protein, humanras ProteinsSREBF1 protein, humanSterol Regulatory Element Binding Protein 1Trans-ActivatorsTranscription Factorsgeneticsgenome-wide association studiesmultiethnicobstructive sleep apneasexual dimorphism

Identifiers

PMID29077507
PMCPMC5854957
OpenAlexW2765575792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.