Evidence map›Paper›PMID 29077068›Full record

ArticleInternational journal of molecular sciences2017

Reg Gene Expression in Periosteum after Fracture and Its In Vitro Induction Triggered by IL-6.

Yasuaki Tohma, Yoshiko Dohi, Ryogo Shobatake, Tomoko Uchiyama, Maiko Takeda, Shin Takasawa, Yasuhito Tanaka, Hajime Ohgushi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Upregulation ofInternational journal of molecular sciences · 2022
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  9. Intermittent Hypoxia Upregulates theInternational journal of molecular sciences · 2021
    Article
  10. Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular CaProceedings of the Japan Academy. Series B, Physical and biological sciences · 2021
    Article
  11. Article
  12. Krüppel-like factor 3 inhibition by mutated lncRNAThe Journal of experimental medicine · 2019
    Article
  13. Intermittent Hypoxia Up-RegulatesInternational journal of molecular sciences · 2019
    Article
  14. Intermittent Hypoxia Up-Regulates Gene Expressions ofInternational journal of molecular sciences · 2019
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yasuaki TohmaDepartment of Orthopedic Surgery, Nara City Hospital, 1-50-1 Higashikidera-cho, Nara, Nara 630-8305, Japan. yatohma@naramed-u.ac.jp.
Yoshiko DohiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. yoshiko-dohi@aroma.ocn.ne.jp.
Ryogo ShobatakeDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. rshobatake@naramed-u.ac.jp.
Tomoko UchiyamaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. uchiyama0403@naramed-u.ac.jp.
Maiko TakedaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. maikot@naramed-u.ac.jp.
Shin TakasawaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. shintksw@naramed-u.ac.jp.ORCID 0000-0002-4066-0199
Yasuhito TanakaDepartment of Orthopedic Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. yatanaka@naramed-u.ac.jp.ORCID 0000-0002-2300-611X
Hajime OhgushiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. hajime-ohgushi@aist.go.jp.
Nara Medical University · JPKuma Hospital · JPNara City Hospital · JPNHO Kinki Chuo Chest Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The periosteum is a thin membrane that surrounds the outer surface of bones and participates in fracture healing. However, the molecular signals that trigger/initiate the periosteal reaction are not well established. We fractured the rat femoral bone at the diaphysis and fixed it with an intramedullary inserted wire, and the expression of regenerating gene (

Indexed as

Fracture HealingGene Expression RegulationAnimalsApoptosisBcl-2-Like Protein 11Cells, CulturedDisease Models, AnimalFractures, BoneGene Expression ProfilingImmunohistochemistryInterleukin-6LithostathineMaleMesenchymal Stem CellsPeriosteumRatsBcl-2-Like Protein 11Interleukin-6LithostathineReg1a protein, ratRNA, MessengerBimbone regenerationfractureIL-6periosteumReg (regenerating gene)

Identifiers

PMID29077068
PMCPMC5713227
OpenAlexW2765537170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.