Evidence map›Paper›PMID 29077051›Full record

ArticleToxins2017

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.

David Wilson, Glen M Boyle, Lachlan McIntyre, Matthew J Nolan, Peter G Parsons, Jennifer J Smith, Leon Tribolet, Alex Loukas, Michael J Liddell, Lachlan D Rash and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. A venom fraction from the Philippine tarantula (The journal of venomous animals and toxins including tropical diseases · 2026
    Article
  2. Article
  3. The role of polyamine metabolism in cellular function and physiology.American journal of physiology. Cell physiology · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Brazilian Theraphosidae: a toxicological point of view.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  10. Article
  11. The journal of venomous animals and toxins including tropical diseases · 2020
    Article
  12. Article
  13. Review
  14. Venomics: A Mini-Review.High-throughput · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

David WilsonCentre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, QLD 4878, Australia. david.wilson4@jcu.edu.au.
Glen M BoyleQIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia. Glen.Boyle@qimrberghofer.edu.au.ORCID 0000-0002-1385-529X
Lachlan McIntyreCentre for Tropical Environmental and Sustainable Sciences, James Cook University, Cairns, QLD 4878, Australia. lach.mcintyre@gmail.com.
Matthew J NolanCentre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, QLD 4878, Australia. mjnolan78@gmail.com.ORCID 0000-0002-5353-7712
Peter G ParsonsQIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia. Peter.Parsons@qimr.edu.au.ORCID 0000-0002-0473-3346
Jennifer J SmithInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. jennifer.smith@imb.uq.edu.au.
Leon TriboletCentre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, QLD 4878, Australia. leon.tribolet@gmail.com.
Alex LoukasCentre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, QLD 4878, Australia. alex.loukas@jcu.edu.au.
Michael J LiddellCentre for Tropical Environmental and Sustainable Sciences, James Cook University, Cairns, QLD 4878, Australia. michael.liddell@jcu.edu.au.
Lachlan D RashInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. l.rash@uq.edu.au.ORCID 0000-0003-3616-0279
Norelle L DalyCentre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University, Cairns, QLD 4878, Australia. norelle.daly@jcu.edu.au.
Australian Institute of Tropical Health and Medicine · AUJames Cook University · AUQIMR Berghofer Medical Research Institute · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA

Indexed as

AnimalsCell Line, TumorCell SurvivalFemaleHumansMagnetic Resonance SpectroscopyPolyaminesSpidersSpider VenomsPolyaminesSpider VenomscancercytotoxicityNMR spectroscopypolyaminespider venom

Identifiers

PMID29077051
PMCPMC5705961
OpenAlexW2766672915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.