ReviewThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2018
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.
Abstract readReviewConsensus Statement
In one paragraph
Review in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
154 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Mass Spectrometry as a Quantitative Proteomic Analysis Tool for the Search for Temporal Lobe Epilepsy Biomarkers: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.Frontiers in neurology · 2021Pooled it
- Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2019Guideline
- CLIC1 Protein Accumulates in Circulating Monocyte Membrane during Neurodegeneration.International journal of molecular sciences · 2020Trial
- Structural MRI in frontotemporal dementia and Alzheimer's disease: stage-dependent atrophy patterns.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Thalamic nuclei insights into Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal Study of Plasma NFL and GFAP as Biomarkers of Alcohol Withdrawal-Associated Brain Injury.Addiction biology · 2026Observational
- Advancing diagnostic biomarkers in Alzheimer's disease: interdisciplinary innovations and technological frontiers.Human cell · 2026Review
- Nano-based spectroscopic approaches for early diagnosis of Alzheimer's disease: critical insights into amyloid-β and tau biomarker biology and detection tools.Biophysical reviews · 2026Review
- Domain-adapted language model using reinforcement learning for various dementias.medRxiv : the preprint server for health sciences · 2026Article
- Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2.Scientific reports · 2026Article
- GRAD: A Two-Stage Algorithm for Resolving Diagnostic Uncertainty in the Plasma p-tau217 Gray Zone.medRxiv : the preprint server for health sciences · 2026Article
- The 2024 NIA-AA biological definition of Alzheimer's disease: linking biomarkers to clinical practice.Frontiers in dementia · 2026Review
- Causal relationships between cerebrospinal fluid metabolites, immune cell traits, and head and neck cancers.Discover oncology · 2025Article
- Reliable New Biomarkers of Mitochondrial Oxidative Stress and Neuroinflammation in Cerebrospinal Fluid and Plasma from Alzheimer's Disease Patients: A Pilot Study.International journal of molecular sciences · 2025Article
- Use of Proteomics to Explore Biomarkers of Amyotrophic Lateral Sclerosis (ALS): Proof of Principle from Humanized SOD1 Mouse to Human ALS.ACS pharmacology & translational science · 2025Review
- Linking Lymphedema, Chronic Inflammation, Oxidative Stress, Alzheimer Disease, and Potential Role of Lymphaticovenous Anastomosis.Plastic and reconstructive surgery. Global open · 2025Article
- Identification and Validation of Biomarkers for Alzheimer's Disease Based on Akt and Wnt Signaling Pathways in Mouse Models.Molecular neurobiology · 2025Article
- Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.NPJ Parkinson's disease · 2025Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors.
Piotr Lewczuka Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.ORCID 0000-0002-8101-6535
Peter Riedererc Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy , University Hospital Würzburg , Würzburg , Germany.
Sid E O'Bryantd Institute for Healthy Aging , University of North Texas Health Science Center , Fort Worth , TX , USA.
Marcel M Verbeeke Department of Neurology , Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center , Nijmegen , The Netherlands.ORCID 0000-0003-4635-7876
Bruno Duboisg Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Salpêtrièrie Hospital, INSERM UMR-S 975 (ICM), Paris 6 University , Paris , France.
Pieter Jelle Visserh Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Alzheimer Center Limburg, Maastricht University , Maastricht , The Netherlands.
Kurt A Jellingerj Institute of Clinical Neurobiology , Vienna , Austria.
Sebastiaan Engelborghsk Reference Center for Biological Markers of Dementia (BIODEM) , University of Antwerp , Antwerp , Belgium.
Alfredo Ramirezm Department of Psychiatry and Psychotherapy , University of Bonn , Bonn , Germany.ORCID 0000-0003-4991-763X
Lucilla Parnettip Section of Neurology, Center for Memory Disturbances, Lab of Clinical Neurochemistry , University of Perugia , Perugia , Italy.ORCID 0000-0001-5722-3967
Clifford R Jackq Department of Radiology , Mayo Clinic , Rochester , MN , USA.ORCID 0000-0001-7916-622X
Charlotte E Teunissenr Neurochemistry Lab and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience , VU University Medical Center Amsterdam , Amsterdam , The Netherlands.
Harald Hampels AXA Research Fund & UPMC Chair , Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Boulevard de l'hôpital , Paris , France.
Alberto Lleót Department of Neurology , Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona , Barcelona , Spain.ORCID 0000-0002-2568-5478
Frank Jesseno Department of Psychiatry and Psychotherapy , University of Cologne , Cologne , Germany.
Lidia Glodzikw Center for Brain Health, Department of Psychiatry , NYU Langone Medical Center , New York , NY , USA.
Mony J de Leonw Center for Brain Health, Department of Psychiatry , NYU Langone Medical Center , New York , NY , USA.
Anne M Faganx Knight Alzheimer's Disease Research Center , Washington University School of Medicine , Saint Louis , MO , USA.
José Luis Molinuevoz Barcelonabeta Brain Research Center , Pasqual Maragall Foundation , Barcelona , Spain.
Willemijn J Jansenh Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Alzheimer Center Limburg, Maastricht University , Maastricht , The Netherlands.
Bengt Winbladab Karolinska Institutet , Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics , Huddinge , Sweden.
Leslie M Shawac Department of Pathology and Laboratory Medicine, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.
Ulf Andreassonad Clinical Neurochemistry Laboratory , Sahlgrenska University Hospital , Mölndal , Sweden.
Markus Ottoaf Department of Neurology , University of Ulm , Ulm , Germany.
Brit Mollenhauerag Paracelsus-Elena-Klinik, Kassel and University Medical Center Göttingen, Department of Neurology , Göttingen , Germany.
Jens Wiltfangah Department of Psychiatry & Psychotherapy , University of Göttingen , Göttingen , Germany.
Martin R Turnerak Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.
Inga Zerrai German Center for Neurodegenerative Diseases (DZNE) , Göttingen , Germany.
Ron Handelsh Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Alzheimer Center Limburg, Maastricht University , Maastricht , The Netherlands.ORCID 0000-0002-8663-0630
Alexander G Thompsonak Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.ORCID 0000-0003-1063-3277
Gunilla Johanssonab Karolinska Institutet , Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics , Huddinge , Sweden.
Natalia Ermanna Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.
John Q Trojanowskiac Department of Pathology and Laboratory Medicine, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.ORCID 0000-0002-9239-8794
Ilker Karacam Department of Psychiatry and Psychotherapy , University of Bonn , Bonn , Germany.
Holger Wagnerm Department of Psychiatry and Psychotherapy , University of Bonn , Bonn , Germany.
Patrick Oecklaf Department of Neurology , University of Ulm , Ulm , Germany.
Linda van Waalwijk van Doorne Department of Neurology , Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center , Nijmegen , The Netherlands.
Maria Bjerkek Reference Center for Biological Markers of Dementia (BIODEM) , University of Antwerp , Antwerp , Belgium.
Dimitrios Kapogiannisam Laboratory of Neurosciences , National Institute on Aging/National Institutes of Health (NIA/NIH) , Baltimore , MD , USA.
H Bea Kuiperije Department of Neurology , Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center , Nijmegen , The Netherlands.
Lucia Farottip Section of Neurology, Center for Memory Disturbances, Lab of Clinical Neurochemistry , University of Perugia , Perugia , Italy.
Yi Liw Center for Brain Health, Department of Psychiatry , NYU Langone Medical Center , New York , NY , USA.
Brian A Gordonx Knight Alzheimer's Disease Research Center , Washington University School of Medicine , Saint Louis , MO , USA.ORCID 0000-0003-2109-2955
Stéphane Epelbaumg Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Salpêtrièrie Hospital, INSERM UMR-S 975 (ICM), Paris 6 University , Paris , France.
Stephanie J B Vosh Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Alzheimer Center Limburg, Maastricht University , Maastricht , The Netherlands.
Catharina J M Klijne Department of Neurology , Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center , Nijmegen , The Netherlands.
William E Van Nostrandao Department of Neurosurgery, HSC T-12/086 , Stony Brook University , New York , NY , USA.
Carolina Minguillonz Barcelonabeta Brain Research Center , Pasqual Maragall Foundation , Barcelona , Spain.
Matthias Schmitzai German Center for Neurodegenerative Diseases (DZNE) , Göttingen , Germany.
Carla Galloap Departamento de Ciencias Celulares y Moleculares/Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía , Universidad Peruana Cayetano Heredia , Lima , Peru.
Andrea Lopez Matoaq Chair of Psychoneuroimmunoendocrinology , Maimonides University , Buenos Aires , Argentina.
Florence Thibautar Department of Psychiatry , University Hospital Cochin-Site Tarnier 89 rue d'Assas, INSERM 894, Faculty of Medicine Paris Descartes , Paris , France.ORCID 0000-0002-0204-5435
Simone Listas AXA Research Fund & UPMC Chair , Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Boulevard de l'hôpital , Paris , France.
Daniel Alcoleat Department of Neurology , Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona , Barcelona , Spain.ORCID 0000-0002-3819-3245
Henrik Zetterbergad Clinical Neurochemistry Laboratory , Sahlgrenska University Hospital , Mölndal , Sweden.
Kaj Blennowad Clinical Neurochemistry Laboratory , Sahlgrenska University Hospital , Mölndal , Sweden.
Johannes Kornhubera Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.ORCID 0000-0002-8096-3987
Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MTransgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3MPSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAO, YONGZHAO · 1990 to 2019
$36.1MUPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 1991 to 2020
$35.1MStudies in Dementia and Neurodegenerative DiseasesZIAAG000975 · NIA · NATIONAL INSTITUTE ON AGING · PI KAPOGIANNIS, DIMITRIOS · 2009 to 2025
$31.5MProject IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9MHealth Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6MPREDICTORS OF COGNITIVE DECLINE IN NORMAL AGINGR01AG012101 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DE LEON, MONY J., RUSINEK, HENRY · 1993 to 2015
$6.7MMedical Research Council MR/K01014X/1Motor Neurone Disease Association TURNER/JAN13/944-795Motor Neurone Disease Association TURNER/OCT18/989-797NIA NIH HHS K01 AG053474NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG012101NIA NIH HHS R01 AG013616NIA NIH HHS R01 AG022374NIA NIH HHS R01 AG051848NIA NIH HHS R01 AG054073NIA NIH HHS R56 AG054073NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904NINDS NIH HHS P50 NS053488
Abstract
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-β positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.
Indexed as
BiomarkersBiological PsychiatryDementiaHumansNeurodegenerative DiseasesSocieties, MedicalBiomarkersAlzheimer’s diseasebiomarkerscerebrospinal fluidconsensusdementia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.