Evidence map›Paper›PMID 29076182›Full record

ArticleBiometrical journal. Biometrische Zeitschrift2018

Estimating multiple time-fixed treatment effects using a semi-Bayes semiparametric marginal structural Cox proportional hazards regression model.

Stephen R Cole, Jessie K Edwards, Daniel Westreich, Catherine R Lesko, Bryan Lau, Michael J Mugavero, W Christopher Mathews, Joseph J Eron, Sander Greenland, CNICS Investigators

Abstract read
In one paragraph

Article in Biometrical journal. Biometrische Zeitschrift, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Five Facts About Influence Functions.Epidemiology (Cambridge, Mass.) · 2025
    Article
  2. Illustration of 2 Fusion Designs and Estimators.American journal of epidemiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephen R ColeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-2117-1311
Jessie K EdwardsDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Daniel WestreichDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Catherine R LeskoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Bryan LauDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michael J MugaveroDepartment of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
W Christopher MathewsDepartment of Medicine, School of Medicine, University of California, San Diego, CA, USA.
Joseph J EronDepartment of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Sander GreenlandDepartments of Epidemiology and Statistics, UCLA, Los Angeles, CA, USA.
CNICS Investigators

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Structural models for treatment and exposure effects in clinical HIV cohortsR01AI100654 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COLE, STEPHEN R · 2013 to 2016
$1.6M
Comparative effectiveness of tailored HIV treatment plans and mortalityK01AI125087 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EDWARDS, JESSIE · 2017 to 2021
$586k
NIAID NIH HHS K01 AI125087NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI100654NIAID NIH HHS R24 AI067039
6 · The paper itself

Abstract

Marginal structural models for time-fixed treatments fit using inverse-probability weighted estimating equations are increasingly popular. Nonetheless, the resulting effect estimates are subject to finite-sample bias when data are sparse, as is typical for large-sample procedures. Here we propose a semi-Bayes estimation approach which penalizes or shrinks the estimated model parameters to improve finite-sample performance. This approach uses simple symmetric data-augmentation priors. Limited simulation experiments indicate that the proposed approach reduces finite-sample bias and improves confidence-interval coverage when the true values lie within the central "hill" of the prior distribution. We illustrate the approach with data from a nonexperimental study of HIV treatments.

Indexed as

Models, StatisticalAnti-HIV AgentsBayes TheoremBiometryHIV InfectionsHumansProportional Hazards ModelsRegression AnalysisAnti-HIV Agentsbiascausal inferencecohort studysemi-Bayessemiparametricsurvival analysis

Identifiers

PMID29076182
PMCPMC6771415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.