Evidence map›Paper›PMID 29076046›Full record

ArticleJournal of industrial microbiology & biotechnology2018

Optimization of C16 and C18 fatty alcohol production by an engineered strain of Lipomyces starkeyi.

Bonnie A McNeil, David T Stuart

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Genome-scale model development and genomic sequencing of the oleaginous cladeFrontiers in bioengineering and biotechnology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bonnie A McNeilDepartment of Biochemistry, University of Alberta, 561 Medical Sciences Building, Edmonton, AB, T6G 2H7, Canada.
David T StuartDepartment of Biochemistry, University of Alberta, 561 Medical Sciences Building, Edmonton, AB, T6G 2H7, Canada. dtstuart@ualberta.ca.ORCID 0000-0002-0001-7713
University of Alberta · CA

Funding

Alberta Innovates Bio Solutions Biofutures program BFR078Natural Sciences and Engineering Research Council of Canada I2IPJ 476902Natural Sciences and Engineering Research Council of Canada PDF-471688-2015Networks of Centres of Excellence of Canada BioFuelNet (CA) 57
6 · The paper itself

Abstract

The oleaginous yeast Lipomyces starkeyi was engineered for the production of long-chain fatty alcohols by expressing a fatty acyl-CoA reductase, mFAR1, from Mus musculus. The optimal conditions for production of fatty alcohols by this strain were investigated. Increased carbon-to-nitrogen ratios led to efficient C16 and C18 fatty alcohol production from glucose, xylose and glycerol. Batch cultivation resulted in a titer of 1.7 g/L fatty alcohol from glucose which represents a yield of 28 mg of fatty alcohols per gram of glucose. This relatively high level of production with minimal genetic modification indicates that L. starkeyi may be an excellent host for the bioconversion of carbon-rich waste streams, particularly lignocellulosic waste, to C16 and C18 fatty alcohols.

Indexed as

Aldehyde OxidoreductasesAnimalsCarbonCell EngineeringFatty AlcoholsGlucoseGlycerolLipomycesMiceNitrogenXyloseAldehyde OxidoreductasesCarbonFAR1 protein, mouseFatty AlcoholsGlucoseGlycerolhexadecanal dehydrogenase (acylating)NitrogenXyloseFatty acyl-CoA reductaseFatty alcoholsHexadecanolLipomyces starkeyiOleaginous yeast

Identifiers

PMID29076046
OpenAlexW2765252193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.