Evidence map›Paper›PMID 29075989›Full record

ArticleMolecular and cellular biochemistry2018

Uric acid and obesity-related phenotypes in postmenopausal women.

B Grygiel-Górniak, M Mosor, J Marcinkowska, J Przysławski, J Nowak

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

B Grygiel-GórniakDepartment of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland. bgrygiel@ump.edu.pl.
M MosorDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
J MarcinkowskaDepartment of Molecular Pathology, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
J PrzysławskiDepartment of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland.
J NowakDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
Poznan University of Medical Sciences · PLPolish Academy of Sciences · PL

Funding

The Polish National Science Center (NSC) N404 504 638
6 · The paper itself

Abstract

The aim of this study was to find the genetic, metabolic, and nutritional risk factors, which can be associated with uric acid (UA) level. The risk factors related to uricemia were assessed among 271 postmenopausal women without cardiometabolic disorders and hypolipidemic/hypoglycemic treatment selected from a cohort of 1423 obese postmenopausal women. The bioimpedance analysis and biochemical and genetic analyses were performed in two groups characterized by serum UA ≥ 4 mg/dL (238 μmol/L) and < 4 mg/dL. The TaqMan-based real-time PCR method was applied to assess the role of Pro12Ala of peroxisome proliferation-activated receptor (PPAR)gamma-2 and Trp64Arg of beta-3-adrenergic receptor (ADRB) polymorphisms. Women with UA level ≥ 4 mg/dL were characterized by larger body mass, triceps skinfold, waist circumference, body fat amount, and serum insulin, glucose, and triglyceride levels. There was no difference in dietary habits between the analyzed groups. Body mass, waist circumference, body fat amount, diastolic blood pressure, and serum insulin, glucose, high-density lipoprotein, and triglyceride levels, Homeostasis Model Assessment-Insulin Resistance, and energy from the dietary fat influence the UA level ≥ 4 mg/dL; however, the serum UA was not determined by Pro12Ala and Trp64Arg polymorphism analyses. The model of linear regression revealed that the group characterized by body mass index  ≥ 25 kg/m

Indexed as

ObesityPhenotypePolymorphism, GeneticPostmenopauseAgedFemaleHumansMiddle AgedPPAR gammaReceptors, Adrenergic, beta-1Uric AcidADRB1 protein, humanPPAR gammaReceptors, Adrenergic, beta-1Uric AcidNutritionPostmenopausal womenPro12Ala and Trp64Arg polymorphismsUric acid

Identifiers

PMID29075989
PMCPMC5943388
OpenAlexW2765934717

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.