ReviewEndocrine2017
Lugol's solution and other iodide preparations: perspectives and research directions in Graves' disease.
Review in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04856488 (Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter
Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Therapeutic effectiveness of iodine-rich herbs in treating Graves' hyperthyroidism: a retrospective cohort study from a single center.Frontiers in endocrinology · 2025Trial
- Assessing the impact of short-term Lugol's solution on toxic nodular thyroid disease: a pre-post-intervention study.Frontiers in endocrinology · 2024Trial
- Article
- Early predictors of 6-month thyroid-stimulating antibody levels after radioactive iodine therapy for Graves' disease: implications for pregnancy planning.Endocrine journal · 2026Article
- Approach to the patient with thyroid storm.The Journal of clinical endocrinology and metabolism · 2026Review
- Novel triple-drug regimen for preoperative optimization in giant Graves' disease: a prospective efficacy and safety trial.Gland surgery · 2026Article
- Iopanoic acid rapidly restores euthyroidism in refractory thyrotoxicosis pre-thyroidectomy: a retrospective study.European thyroid journal · 2026Review
- Premedication with Lugol's solution in total thyroidectomy for graves' disease and toxic multinodular goiter: is it still indicated?Updates in surgery · 2026Article
- Lugol's Iodine as a Key Treatment in Transient Gestational Thyrotoxicosis: A Case Report.Case reports in endocrinology · 2026Article
- Study on evaluation of effects of electromagnetic radiation on pollen viability in some commonly occurring plant species following different staining methods.Protoplasma · 2026Article
- Transport of Molecular Iodine From Antiseptic Iodophors across Hydrophilic-lipophilic Interfaces: Influence of Phospholipids.ACS omega · 2025Article
- One Health assessment of zoonotic intestinal parasites in humans, dogs, and soil of coastal Cartagena, Colombia.Veterinary world · 2025Article
- Challenges in the Diagnosis and Management of Graves' Disease in an Elderly Female With Antithyroid Drug Intolerance.Cureus · 2025Article
- PDMS SlipChip: Optimizing Sealing, Slipping, and Biocompatibility Using Low-Viscosity Silicone Oils.Micromachines · 2025Article
- A narrative review of long-term inorganic iodine monotherapy for Graves' disease with a historical relationship between iodine and thyroid.Endocrine journal · 2025Review
- Warming degrades nutritional quality of periphyton in stream ecosystems: evidence from a mesocosm experiment.ISME communications · 2025Article
- Evaluation of the Protective Effects of Lugol's Solution in Rats Poisoned with Aluminum Phosphide (Rice Tablets).Cardiovascular toxicology · 2024Article
- Surgical outcome after thyroidectomy due to Graves' disease and Lugol iodine treatment: a retrospective register-based cohort study.Endocrine · 2024Article
- Efficacy and safety of ultrasound-guided thermal ablation of graves' disease: a retrospective cohort study.Thyroid research · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lugol's solution and other preparations containing iodide have for almost a century been used as an adjuvant treatment in patients with Graves' disease planned for thyroidectomy. Iodide has been shown to decrease thyroid hormone levels and reduce blood flow within the thyroid gland. An escape phenomenon has been feared as the iodide effect has been claimed to only be temporary. Lugol's solution has many additional effects and is used in other settings beside the thyroid. Still, there are questions of its mode of action, which doses should be deployed, if it should be used preoperative in all thyroidectomies or only in a few selected ones if at all, what is its use in other forms of thyrotoxicosis besides Graves' disease, and what is the mechanism acting on the vasculature and if these effects are confined only to arterial vessels supporting the thyroid or not. This review aims to collate current available data about Lugol's solution and other iodide preparations in the management of Graves' disease and give some suggestions where more research is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.