Evidence map›Paper›PMID 29075889›Full record

ArticlePediatric nephrology (Berlin, Germany)2018

Prenatal parental decision-making and postnatal outcome in renal oligohydramnios.

Katrin Mehler, Ingo Gottschalk, Kathrin Burgmaier, Ruth Volland, Anja K Büscher, Markus Feldkötter, Titus Keller, Lutz T Weber, Angela Kribs, Sandra Habbig

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Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
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  4. End-stage kidney disease in infancy: an educational review.Pediatric nephrology (Berlin, Germany) · 2020
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Katrin MehlerNeonatology and Pediatric Intensive Care, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Ingo GottschalkPrenatal Medicine, Department of Obstetrics and Gynecology, University Hospital of Cologne, Cologne, Germany.
Kathrin BurgmaierPediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Ruth VollandPediatric Oncology and Hematology, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Anja K BüscherClinic for Pediatrics II, Pediatric Nephrology, University of Essen, Essen, Germany.
Markus FeldkötterPediatric Nephrology, Children's University Hospital, Bonn, Germany.
Titus KellerNeonatology and Pediatric Intensive Care, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Lutz T WeberPediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Angela KribsNeonatology and Pediatric Intensive Care, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Sandra HabbigPediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany. sandra.habbig@uk-koeln.de.ORCID 0000-0002-6511-5023
University Hospital Cologne · DEEssen University Hospital · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies on renal oligohydramnios (ROH) report highly variable outcome and identify early onset of ROH and presence of extrarenal manifestations as predictors of adverse outcome in most cases. Data on termination of pregnancy (TOP) and associated parental decision-making processes are mostly missing, but context-sensitive for the interpretation of these findings. We provide here a comprehensive analysis on the diagnosis, prenatal decision-making and postnatal clinical course in all pregnancies with ROH at our medical centre over an 8-year period.

methodsWe report retrospective chart review data on 103 consecutive pregnancies from 2008 to 2015 with a median follow-up of 554 days.

resultsAfter ROH diagnosis, 38 families opted for TOP. This decision was associated with onset of ROH (p < 0.001), underlying renal disease (p = 0.001) and presence of extrarenal manifestations (p = 0.02). Eight infants died in utero and 8 cases were lost to follow-up. Of the 49 liveborn children, 11 received palliative and 38 underwent active care. Overall survival of the latter group was 84.2% (n = 32) corresponding to 31% of all pregnancies (32 out of 103) analysed. One third of the surviving infants needed renal replacement therapy during the first 6 weeks of life.

conclusionsOver one third of pregnancies with ROH were terminated and the parental decision was based on risk factors associated with adverse outcome. Neonatal death was rare in the actively treated infants and the overall outcome promising. Our study illustrates that only careful analysis of the whole process, from prenatal diagnosis via parental decision-making to postnatal outcome, allows sensible interpretation of outcome data.

Indexed as

Decision MakingAbortion, InducedAdolescentAdultFemaleHumansInfantInfant MortalityInfant, NewbornKidneyKidney DiseasesMaleOligohydramniosParentsPregnancyPrenatal DiagnosisLung hypoplasiaNeonatal dialysisNewbornPalliative careRenal replacement therapyROHTermination of pregnancy

Identifiers

PMID29075889
OpenAlexW2766221217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.