ArticleBrain and behavior2017
Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Exploring the Relationship Between Deficits in Social Cognition and Neurodegenerative Dementia: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- Disrupted emotion-memory interactions in behavioral variant frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Destination memory in behavioral-variant frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Beauty and Paintings: Aesthetic Experience in Patients with Behavioral Variant Frontotemporal Dementia When Viewing Abstract and Concrete Paintings.Brain sciences · 2024Article
- Understanding the cognitive and neuroimaging bases underlying the detrimental impact of sleep deprivation on reciprocity.iScience · 2024Article
- Real World Financial Mismanagement in Alzheimer's Disease, Frontotemporal Dementia, and Primary Progressive Aphasia.Journal of Alzheimer's disease : JAD · 2024Article
- Reward processing deficits arise early in familial frontotemporal dementia.Frontiers in neuroscience · 2024Article
- The neutral past: emotional (dys)regulation of autobiographical memory in behavioural variant frontotemporal dementia.Cognitive neuropsychiatry · 2023Article
- The Hippocampus Contributes to Temporal Discounting When Delays and Rewards Are Experienced in the Moment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia.Human brain mapping · 2023Article
- Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance.Brain and behavior · 2023Review
- Fairness: from the guts to the brain - a critical examination by Atlantic fellows of the Global Brain Health Institute.Frontiers in psychology · 2023Article
- Pupillometry as an index for cognitive processing in behavioral variant FrontoTemporal Dementia: a series of case studies.Neurocase · 2022Article
- Social cognition in the FTLD spectrum: evidence from MRI.Journal of neurology · 2022Review
- Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review.Movement disorders clinical practice · 2021Review
- Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.Brain communications · 2021Review
- Behavioural Variant Frontotemporal Dementia: Recent Advances in the Diagnosis and Understanding of the Disorder.Advances in experimental medicine and biology · 2021Review
- Altered phobic reactions in frontotemporal dementia: A behavioural and neuroanatomical analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Neurodegenerative Disease and the Experience of Homelessness.Frontiers in neurology · 2020Article
- Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes.Social cognitive and affective neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
introductionEmpathy and shared feelings of reward motivate individuals to share resources with others when material gain is not at stake. Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disease that affects emotion- and reward-relevant neural systems. Although there is diminished empathy and altered reward processing in bvFTD, how the disease impacts prosocial behavior is less well understood.
methodsA total of 74 participants (20 bvFTD, 15 Alzheimer's disease [AD], and 39 healthy controls) participated in this study. Inspired by token-based paradigms from animal studies, we developed a novel task to measure prosocial giving (the "Giving Game"). On each trial of the Giving Game, participants decided how much money to offer to the experimenter, and prosocial giving was the total amount that participants gave to the experimenter when it cost them nothing to give. Voxel-based morphometry was then used to identify brain regions that were associated with prosocial giving.
resultsProsocial giving was lower in bvFTD than in healthy controls; prosocial giving in AD did not differ significantly from either of the other groups. Whereas lower prosocial giving was associated with atrophy in the right pulvinar nucleus of the thalamus, greater prosocial giving was associated with atrophy in the left ventral striatum.
conclusionThese findings suggest that simple acts of generosity deteriorate in bvFTD due to lateralized atrophy in reward-relevant neural systems that promote shared feelings of positive affect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.