Raloxifene Improves Cognition in Schizophrenia: Spurious Result or Valid Effect?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

1. Specificity proteins 1 and 4 in peripheral blood mononuclear cells in postmenopausal women with schizophrenia: a 24-week double-blind, randomized, parallel, placebo-controlled trial.European archives of psychiatry and clinical neuroscience · 2019
   Trial
2. Sex-informed estrogen receptor modulation in schizophrenia: a male-focused ERβ/GPER1 framework for cognitive and negative symptoms.Frontiers in psychiatry · 2025
   Article
3. Effects of estrogen and raloxifene on synaptic density in the hippocampal CA1 region of ovariectomized rats.Clinics (Sao Paulo, Brazil) · 2023
   Article
4. Estrogens in schizophrenia: progress, current challenges and opportunities.Current opinion in psychiatry · 2021
   Review
5. Raloxifene augmentation in men and women with a schizophrenia spectrum disorder: A study protocol.Contemporary clinical trials communications · 2020
   Article
6. Neuropsychiatric effects of tamoxifen: Challenges and opportunities.Frontiers in neuroendocrinology · 2020
   Review
7. Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress in Schizophrenia.Molecular neuropsychiatry · 2019
   Article
8. Women who suffer from schizophrenia: Critical issues.World journal of psychiatry · 2018
   Review
9. The effect of raloxifene augmentation in men and women with a schizophrenia spectrum disorder: a systematic review and meta-analysis.NPJ schizophrenia · 2018
   Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors at 2 institutions in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as