ArticleFrontiers in psychiatry2017
White Matter Integrity Deficit Associated with Betel Quid Dependence.
Article in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Altered Functional Connectivity in the Reward Circuit in Betel Quid-Dependent Chewers.Addiction biology · 2026Article
- Understanding betel nut addiction: a review of harmful consequences, underlying neurobiology, and emerging intervention strategies.Translational psychiatry · 2026Review
- Relating white matter microstructure in theoretically defined addiction networks to relapse in alcohol use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Association between white matter microstructure and cognitive function in patients with methamphetamine use disorder.Human brain mapping · 2023Article
- Mapping white matter structural and network alterations in betel quid-dependent chewers using high angular resolution diffusion imaging.Frontiers in psychiatry · 2022Article
- A multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers.Brain imaging and behavior · 2021Article
- Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations.International journal of environmental research and public health · 2020Review
- Dysfunction of the Prefrontal Cortex in Betel-Quid-Dependent Chewers.Frontiers in psychiatry · 2020Article
- Reduced Cortical Thickness in the Right Caudal Middle Frontal Is Associated With Symptom Severity in Betel Quid-Dependent Chewers.Frontiers in psychiatry · 2020Article
- Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals.Frontiers in human neuroscience · 2020Article
- Structural and Functional Alterations in Betel-Quid Chewers: A Systematic Review of Neuroimaging Findings.Frontiers in psychiatry · 2019Article
- Structural and Functional Connectivity Between the Amygdala and Orbital Frontal Cortex in Burning Mouth Syndrome: An fMRI Study.Frontiers in psychology · 2019Article
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Authors and funding
6 authors.
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Abstract
Betel quid (BQ) is a commonly consumed psychoactive substance, which has been regarded as a human carcinogen. Long-term BQ chewing may cause Diagnostic and Statistical Manual of Mental Disorders-IV dependence symptoms, which can lead to decreased cognitive functions, such as attention and inhibition control. Although betel quid dependence (BQD) individuals have been reported with altered brain structure and function, there is little evidence showing white matter microstructure alternation in BQD individuals. The present study aimed to investigate altered white matter microstructure in BQD individuals using diffusion tensor imaging. Tract-based spatial statistics was used to analyze the data. Compared with healthy controls, BQD individuals exhibited higher mean diffusivity (MD) in anterior thalamic radiation (ATR). Further analysis revealed that the ATR in BQD individuals showed less fractional anisotropy (FA) than that in healthy controls. Correlation analysis showed that both the increase of MD and reduction of FA in BQD individuals were associated with severity of BQ dependence. These results suggested that BQD would disrupt the balance between prefrontal cortex and subcortical areas, causing declined inhibition control.
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