ArticleFrontiers in psychiatry2017
Abnormal Resting-State Functional Connectivity of Insular Subregions and Disrupted Correlation with Working Memory in Adults with Attention Deficit/Hyperactivity Disorder.
Article in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Electrophysiological Brain Changes Associated With Cognitive Improvement in a Pediatric Attention Deficit Hyperactivity Disorder Digital Artificial Intelligence-Driven Intervention: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Individualised Structural and Functional Frontostriatal Connectivity Mapping in Adult ADHD.Human brain mapping · 2026Article
- The association between fronto-insular interaction and executive function during childhood and adolescence in a resting state fMRI study.Scientific reports · 2025Article
- Vulnerable brain regions in adolescent attention deficit hyperactivity disorder: An activation likelihood estimation meta-analysis.World journal of psychiatry · 2025Article
- Phase-lagged tACS between executive and default mode networks modulates working memory.Scientific reports · 2025Article
- Functional connectivity of the pediatric brain.Neuroradiology · 2024Review
- Controllability in attention deficit hyperactivity disorder brains.Cognitive neurodynamics · 2024Article
- Symptom-guided multimodal neuroimage fusion patterns in children with attention-deficit/hyperactivity disorder and its potential "brain structure-function-cognition-behavior" pathological pathways.European child & adolescent psychiatry · 2024Article
- Autism-associated brain differences can be observed in utero using MRI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Age-related positive emotional reactivity decline associated with the anterior insula based resting-state functional connectivity.Human brain mapping · 2024Article
- Altered brain functional connectivity in patients with resistance to thyroid hormone ß.PloS one · 2024Article
- Differences between subclinical attention-deficit/hyperactivity and autistic traits in default mode, salience, and frontoparietal network connectivities in young adult Japanese.Scientific reports · 2023Article
- Altered morphological characteristics and structural covariance connectivity associated with verbal working memory performance in ADHD children.The British journal of radiology · 2023Article
- Simultaneous cluster structure learning and estimation of heterogeneous graphs for matrix-variate fMRI data.Biometrics · 2023Article
- Associations between levels of Internet Gaming Disorder symptoms and striatal morphology-replication and associations with social anxiety.Psychoradiology · 2022Article
- Distinct neural responses of morningness and eveningness chronotype to homeostatic sleep pressure revealed by resting-state functional magnetic resonance imaging.CNS neuroscience & therapeutics · 2022Article
- Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder.Frontiers in neuroscience · 2022Article
- Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis.Frontiers in neuroscience · 2022Article
- Brain connectivity alteration detection via matrix-variate differential network model.Biometrics · 2021Article
- A transdiagnostic data-driven study of children's behaviour and the functional connectome.Developmental cognitive neuroscience · 2021Article
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11 authors.
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Abstract
objectivesExecutive function (EF) deficits are major impairments in adults with attention deficit/hyperactivity disorder (ADHD). Previous studies have shown that the insula is involved in cognitive and EFs. However, the insula is highly heterogeneous in function, and few studies have focused on functional networks which related to specific insular subregions in adults with ADHD. We explored the functional networks of the insular subregions [anterior insula (AI), mid-insula (MI), and posterior insula (PI)]. Furthermore, their correlations with self-ratings of ecological EFs, including inhibition, shifting, and working memory were investigated.
methodsResting-state functional magnetic resonance imaging data in 28 adults with ADHD and 30 matched healthy controls (HCs) were analyzed. The seed-based resting-state functional connectivity (RSFC) of the insular subregions was evaluated. We also investigated their associations with the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) inhibition, working memory, and shifting factor scores.
resultsCompared with HCs, adults with ADHD showed altered RSFC of the AI, with the precuneus, precentral gyrus, and inferior temporal gyrus extended to the middle temporal gyrus, lingual gyrus, and superior occipital gyrus, respectively. There were no significant differences in RSFC of the MI and PI between the two groups. Within the HC group, working memory scores were associated with the RSFC of AI with precuneus and temporal gyrus. However, there was no correlation between these variables in the ADHD group.
conclusionThe study evaluated RSFC patterns of the insular subregions in adults with ADHD for the first time. Altered RSFC of the AI which is a crucial region of salience network (SN) and part of regions in default mode network (DMN), were detected in adults with ADHD in both results with and without global signal regression (GSR), suggesting that disrupted SN-DMN functional connectivity may be involved in EF impairments in adults with ADHD, especially with respect to working memory. Deficits of the AI which is involved in salient stimuli allocation, might be associated with the pathophysiology of ADHD. The inconsistent results of MI and PI between analyses with and without GSR need further exploration.
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