Evidence map›Paper›PMID 29075117›Full record

ArticleNeuropsychiatric disease and treatment2017

Need for medication to complement catecholamines in smoking cessation of hardcore smokers.

Atsuko Kawai, Masatake Kurita, Satoshi Nishino, Eishin Hirata, Tadahiro Sato, Yoshiro Okubo

Open access · goldAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Atsuko KawaiDepartment of Psychiatry and Behavioral Science, Nippon Medical School, Bunkyo-ku.
Masatake KuritaDepartment of Psychiatry and Behavioral Science, Nippon Medical School, Bunkyo-ku.
Satoshi NishinoNatori Station Front Clinic, Natori.
Eishin HirataSato Hospital, Nanyo, Japan.
Tadahiro SatoSato Hospital, Nanyo, Japan.
Yoshiro OkuboDepartment of Psychiatry and Behavioral Science, Nippon Medical School, Bunkyo-ku.
Nippon Medical School · JPSatou Hospital · JPTohoku University · JPTotal (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many smokers find it difficult to stop smoking without assistance. The antidepressants bupropion and nortriptyline can aid smoking cessation. The main aim of this study was to understand the pathophysiology of smoking cessation better based on biological backgrounds. We investigated the following biological markers for any alterations during smoking cessation in the absence of pharmacotherapy: the dopamine metabolite homovanillic acid (HVA), the noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and brain-derived neurotrophic factor (BDNF). Assessment and blood sampling were performed at a baseline (the start) time point and at a critical time point during smoking cessation. Seven of 30 smokers quit during a 16-week follow-up period; these smokers were defined as remission group from tobacco dependence. The remaining 23 smokers were categorized as hardcore smokers. The smoking group was compared with 23 non-smokers matched for age and gender. We compared blood levels of biological markers in each of the three groups. The hardcore smoker group showed significant decreases in HVA and MHPG levels between baseline and the critical time point (

Indexed as

brain-derived neurotrophic factordopaminenicotinenoradrenalinetobaccowithdrawal symptoms

Identifiers

PMID29075117
PMCPMC5609788
OpenAlexW2755915354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.