Evidence map›Paper›PMID 29075102›Full record

ArticleDrug design, development and therapy2017

5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction.

Amit K Keshari, Ashok K Singh, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash and 1 more

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Poly(lactic-International journal of nanomedicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Amit K KeshariDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University.
Ashok K SinghDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University.
Umesh KumarCentre of Biomedical Research, SGPGIMS Campus.
Vinit RajDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University.
Amit RaiDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University.
Pranesh KumarDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University.
Dinesh KumarCentre of Biomedical Research, SGPGIMS Campus.
Biswanath MaityCentre of Biomedical Research, SGPGIMS Campus.
Sneha NathDepartment of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Anand PrakashDepartment of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Sudipta SahaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University.
Babasaheb Bhimrao Ambedkar University · INCentre of Biomedical Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5H-benzo[h]thiazolo[2,3-b]quinazoline scaffold is known to have an antitumor effect on certain types of malignancies; however, its effect on hepatocellular carcinoma (HCC) remains unclear. Previously, we reported

Indexed as

AnimalsAntineoplastic AgentsCarcinoma, HepatocellularDiethylnitrosamineDown-RegulationGene Expression Regulation, NeoplasticInflammation MediatorsInjections, IntraperitonealInterleukin-6Liver Neoplasms, ExperimentalMaleMetabolomicsOxidation-ReductionOxidative StressQuinazolinesRatsAntineoplastic AgentsDiethylnitrosamineInflammation MediatorsInterleukin-6Quinazolines1H-NMR based metabolomics5H-benzo[h]thiazolo[2,3-b]quinazolineHCChepatocellular carcinomainterleukinsNDEAN-nitrosodiethylamine

Identifiers

PMID29075102
PMCPMC5648320
OpenAlexW2761894563

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.