ArticleScientific reports2017
Motor recovery after activity-based training with spinal cord epidural stimulation in a chronic motor complete paraplegic.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02339233 (Spinal Epidural Electrode Array to Facilitate Standing and Stepping After Spinal Cord Injury), which is not on this map. Cited by 108 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After Spinal Cord Injury
Who cites it
108 citing papers in PubMed, 172 citations in OpenAlex.
- Functional outcomes and participants' perspectives during short-term application of spinal stimulation in individuals with spinal cord injury.The journal of spinal cord medicine · 2025Trial
- Transspinal direct current stimulation alters neuronal excitability but not homosynaptic inhibition in human spinal cord injury: a pilot clinical trial.Experimental brain research · 2025Trial
- Activity-based recovery training with spinal cord epidural stimulation improves standing performance in cervical spinal cord injury.Journal of neuroengineering and rehabilitation · 2025Trial
- Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.Nature medicine · 2024Trial
- Trial
- Training with noninvasive brain-machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study.Scientific reports · 2022Trial
- Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury.Brain : a journal of neurology · 2020Trial
- Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis.Journal of neurotrauma · 2019Trial
- Non-Invasive Activation of Cervical Spinal Networks after Severe Paralysis.Journal of neurotrauma · 2018Trial
- Cervicothoracic trans-spinal magnetic stimulation: effect of coil position and orientation on spinal motor evoked potentials.Experimental brain research · 2026Article
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Spinal epidural electrical stimulation for the recovery of motor function in lower limbs after spinal cord injury: A pilot study.The journal of spinal cord medicine · 2026Article
- Spinal cord lesion characteristics and early standing ability with and without epidural stimulation.Experimental brain research · 2026Article
- Review
- Virtual prototyping of non-invasive spinal cord electrical stimulation targeting upper limb motor function.bioRxiv : the preprint server for biology · 2026Article
- The Interplay Between Neuromodulation and Stem Cell Therapy for Sensory-Motor Neuroplasticity After Spinal Cord Injury: A Perspective View.Journal of clinical medicine · 2026Article
- Robotic trunk perturbation magnitude affects standing postural responses in individuals with motor complete spinal cord injury receiving epidural stimulation.Scientific reports · 2026Article
- Non-invasive closed-loop spinal stimulation restores leg stepping control in humans with paraplegia.Brain : a journal of neurology · 2026Article
- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The prognosis for recovery of motor function in motor complete spinal cord injured (SCI) individuals is poor. Our research team has demonstrated that lumbosacral spinal cord epidural stimulation (scES) and activity-based training can progressively promote the recovery of volitional leg movements and standing in individuals with chronic clinically complete SCI. However, scES was required to perform these motor tasks. Herein, we show the progressive recovery of voluntary leg movement and standing without scES in an individual with chronic, motor complete SCI throughout 3.7 years of activity-based interventions utilizing scES configurations customized for the different motor tasks that were specifically trained (standing, stepping, volitional leg movement). In particular, this report details the ongoing neural adaptations that allowed a functional progression from no volitional muscle activation to a refined, task-specific activation pattern and movement generation during volitional attempts without scES. Similarly, we observed the re-emergence of muscle activation patterns sufficient for standing with independent knee and hip extension. These findings highlight the recovery potential of the human nervous system after chronic clinically motor complete SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.