ArticleNature communications2017
Engineering a synthetic pathway for maleate in Escherichia coli.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
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- Production of (R)-citramalate by engineeredMetabolic engineering communications · 2024Article
- Construction and Application of a Multienzyme System for Synthesis of L-malate.Applied biochemistry and biotechnology · 2024Article
- A self-regulated network for dynamically balancing multiple precursors in complex biosynthetic pathways.Metabolic engineering · 2024Article
- Styrene Production in Genetically EngineeredBiotech (Basel (Switzerland)) · 2024Article
- A comprehensive review and comparison of L-tryptophan biosynthesis inFrontiers in bioengineering and biotechnology · 2023Review
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- Advances in engineering microbial biosynthesis of aromatic compounds and related compounds.Bioresources and bioprocessing · 2021Review
- Direct 1,3-butadiene biosynthesis in Escherichia coli via a tailored ferulic acid decarboxylase mutant.Nature communications · 2021Article
- Review
- Engineering a Synthetic Pathway for Gentisate inFrontiers in bioengineering and biotechnology · 2020Article
- Developing a pyruvate-driven metabolic scenario for growth-coupled microbial production.Metabolic engineering · 2019Article
- Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production.Nature communications · 2019Article
- Enhanced biosynthesis of arbutin by engineering shikimate pathway in Pseudomonas chlororaphis P3.Microbial cell factories · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maleate is one of the most important dicarboxylic acids and is used to produce various polymer compounds and pharmaceuticals. Herein, microbial production of maleate is successfully achieved, to our knowledge for the first time, using genetically modified Escherichia coli. A synthetic pathway of maleate is constructed in E. coli by combining the polyketide biosynthesis pathway and benzene ring cleavage pathway. The metabolic engineering approach used to fine-tune the synthetic pathway drastically improves maleate production and demonstrates that one of the rate limiting steps exists in the conversion of chorismate to gentisate. In a batch culture of the optimised transformant, grown in a 1-L jar fermentor, the amount of produced maleate reaches 7.1 g L
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.