ArticleScience (New York, N.Y.)2017
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.
Open access · hybridAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 202 citations in OpenAlex.
- Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future.Medicinal research reviews · 2026Review
- Dual plasmepsin IX and X inhibitors are refractory to development of resistance.PLoS pathogens · 2026Article
- Deconstruction of Aspartic Protease Inhibitors Enables Fragment-Based Discovery of Plasmepsin V Inhibitors.ChemMedChem · 2026Article
- The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis.Nature communications · 2026Article
- Article
- The inner membrane complex protein, IMC55, is dispensable for intraerythrocytic development ofMicrobiology spectrum · 2026Article
- Conformational Dynamics of Plasmepsin X during Inhibitor Binding.The journal of physical chemistry. B · 2026Article
- Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress.PLoS pathogens · 2026Article
- Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases.Nature microbiology · 2026Article
- Article
- Unlocking the Enigmas ofCurrent pharmaceutical design · 2026Article
- Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics inACS infectious diseases · 2025Article
- Article
- An overview of the interconnectedness of the PEXEL and non-PEXEL mediated protein export iniScience · 2025Review
- Aspartyl protease inhibition interferes with Plasmodium falciparum asexual blood-stage and early gametocyte development.Malaria journal · 2025Article
- A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies.Nature communications · 2025Article
- Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors.The FEBS journal · 2025Article
- Parasite and vector circadian clocks mediate efficient malaria transmission.Nature microbiology · 2025Article
- Synthesis of β-fluoropyrrolidines designed to reduce hERG affinity in a class of antiparasitic compounds.ChemistrySelect · 2025Article
- Towards next-generation treatment options to combat Plasmodium falciparum malaria.Nature reviews. Microbiology · 2025Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
13 authors at 5 institutions in 2 countries.
Armiyaw S NasamuDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-0719-8473
Svetlana GlushakovaSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5662-3384
Ilaria RussoFaculty of Biology, Medicine and Health, Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-2269-7078
Barbara VaupelDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Anna OksmanDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Arthur S KimDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-4101-6642
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Niraj ToliaDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Josh R BeckDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Marvin J MeyersCenter for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.ORCID 0000-0001-5484-619X
Jacquin C NilesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-6250-8796
Joshua ZimmerbergSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1707-3789
Daniel E GoldbergDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA. dgoldberg@wustl.edu.ORCID 0000-0003-3529-8399
Washington University in St. Louis · USNational Institutes of Health · USManchester Academic Health Science Centre · GBMassachusetts Institute of Technology · USSaint Louis University · US
Funding
Membrane Remodeling in Viral Infection, Parasite Replication, and Traumatic Brain InjuryZIAHD001409 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ZIMMERBERG, JOSHUA · 2009 to 2025
$29.9MMIT Center for Integrative Synthetic BiologyP50GM098792 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISS, RON · 2013 to 2017
$11.0MPlasmepsin X function in PlasmodiumR01AI138447 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2018 to 2022
$1.9MIDENTIFICATION OF THE ANTIMALARIAL TARGET OF PEPSTATIN ESTERSR01AI112508 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2014 to 2018
$1.9MErythrocyte Subversion by Malaria Parasite Exported EffectorsR00HL133453 · NHLBI · IOWA STATE UNIVERSITY · PI BECK, JOSH RYAN · 2017 to 2019
$747kErythrocyte Subversion by Malaria Parasite Exported EffectorsK99HL133453 · NHLBI · WASHINGTON UNIVERSITY · PI BECK, JOSH RYAN · 2016 to 2017
$166kNHLBI NIH HHS K99 HL133453NHLBI NIH HHS R00 HL133453NIAID NIH HHS R01 AI112508NIAID NIH HHS R01 AI138447NIGMS NIH HHS P50 GM098792
Abstract
Proteases of the malaria parasite
Indexed as
Administration, OralAnimalsAntimalarialsAspartic Acid EndopeptidasesDisease Models, AnimalErythrocytesMalaria, FalciparumMicePlasmodium falciparumProtozoan ProteinsSubtilisinsAntimalarialsAspartic Acid EndopeptidasesplasmepsinProtozoan Proteinssubtilisin-like protease 1, Plasmodium falciparumSubtilisins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.