ArticleThe EMBO journal1988
DNA rearrangement of a homeobox gene in myeloid leukaemic cells.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 144 citations in OpenAlex.
- Hoxb8 regulates expression of microRNAs to control cell death and differentiation.Cell death and differentiation · 2013Article
- Insertional gene activation by lentiviral and gammaretroviral vectors.Journal of virology · 2009Article
- Homeobox gene expression and mutation in cervical carcinoma cells.Cancer science · 2003Article
- Article
- Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.Journal of virology · 2001Article
- Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos.Oncogene · 2001Article
- Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression.Molecular and cellular biology · 2000Article
- Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.The EMBO journal · 1998Article
- Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.Molecular and cellular biology · 1997Article
- Hox genes in the lung.American journal of respiratory cell and molecular biology · 1996Review
- The control of hematopoiesis and leukemia: from basic biology to the clinic.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Co-amplification to tail-to-tail copies of MuRVY and IAPE retroviral genomes on the Mus musculus Y chromosome.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- A novel non-mouse mammary tumor virus activation of the Int-3 gene in a spontaneous mouse mammary tumor.Journal of virology · 1995Article
- Transformation by homeobox genes can be mediated by selective transcriptional repression.The EMBO journal · 1994Article
- Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.Molecular and cellular biology · 1994Article
- Activation of the mouse mdr3 gene by insertion of retroviruses in multidrug-resistant P388 tumor cells.Molecular and cellular biology · 1993Article
- Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.The EMBO journal · 1993Article
- Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene.The Journal of experimental medicine · 1993Article
- The oncogenic potential of Pax genes.The EMBO journal · 1993Article
- The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A homeobox gene rearrangement has been detected in WEHI-3B mouse myeloid leukaemic cells. The rearranged gene was identified as Hox-2.4 which is a member of the Hox-2 gene cluster on mouse chromosome 11. Both the normal and the rearranged genes were cloned and analysed, and the rearranged genomic Hox-2.4 gene was sequenced. The results indicate that the rearrangement is due to insertion of an intracisternal A particle 5' upstream to Hox-2.4 and that this resulted in constitutive expression of the homeobox gene. It is suggested that constitutive expression of the homeobox gene may interrupt the normal development program in these leukaemic cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.