Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2018
Potential for noninvasive assessment of lung inhomogeneity using highly precise, highly time-resolved measurements of gas exchange.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05531253 (An Observational Study of the Relationship Between Respired Gases, Mixed Venous Oxygen Content and Cardiac Output in Mechanically Ventilated Patients Post Cardiac Surgery), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Study of the Relationship Between Respired Gases, Mixed Venous Oxygen Content and Cardiac Output in Mechanically Ventilated Patients Post Cardiac Surgery
Who cites it
18 citing papers in PubMed.
- The search for the ultra-elusive: Can computed cardiopulmonography enhance early detection of gas exchange abnormality?Experimental physiology · 2026Article
- Computed cardiopulmonography: Effects of physical characteristics on lung parameter estimates.Experimental physiology · 2026Article
- Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma.BMJ open respiratory research · 2025Observational
- Article
- Quantifying heterogeneity in an animal model of acute respiratory distress syndrome, a comparison of inspired sinewave technique to computed tomography.Scientific reports · 2024Article
- Computed cardiopulmonography and the idealized lung clearance index, iLCIJournal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Pathophysiology and Clinical Meaning of Ventilation-Perfusion Mismatch in the Acute Respiratory Distress Syndrome.Biology · 2022Review
- Altered lung physiology in two cohorts after COVID-19 infection as assessed by computed cardiopulmonography.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- The Lognormal Lung: A new approach to quantifying lung inhomogeneity in COPD.Frontiers in physiology · 2022Article
- Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test.Scientific reports · 2021Article
- A dynamic model of the body gas stores for carbon dioxide, oxygen, and inert gases that incorporates circulatory transport delays to and from the lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output.Scientific reports · 2021Article
- Bedside monitoring of lung volume available for gas exchange.Intensive care medicine experimental · 2021Article
- Novel measure of lung function for assessing disease activity in asthma.BMJ open respiratory research · 2020Article
- A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test.PLoS computational biology · 2019Article
- Modeling Pulmonary Gas Exchange and Single-Exhalation Profiles of Carbon Monoxide.Frontiers in physiology · 2018Article
- Laser spectroscopy for breath analysis: towards clinical implementation.Applied physics. B, Lasers and optics · 2018Article
- Assessment of Ventilatory Heterogeneity in Chronic Obstructive Pulmonary Disease Using the Inspired Sinewave Test.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesized that highly precise measurements of gas exchange contain sufficient information to quantify many aspects of the inhomogeneity noninvasively. Our aim was to explore whether one parameterization of lung inhomogeneity could both fit such data and provide reliable parameter estimates. A mathematical model of gas exchange in an inhomogeneous lung was developed, containing inhomogeneity parameters for compliance, vascular conductance, and dead space, all relative to lung volume. Inputs were respiratory flow, cardiac output, and the inspiratory and pulmonary arterial gas compositions. Outputs were expiratory and pulmonary venous gas compositions. All values were specified every 10 ms. Some parameters were set to physiologically plausible values. To estimate the remaining unknown parameters and inputs, the model was embedded within a nonlinear estimation routine to minimize the deviations between model and data for CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.