Evidence map›Paper›PMID 29074707›Full record

ArticleThe Journal of cell biology2018

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.

Bernhard Strauss, Andrew Harrison, Paula Almeida Coelho, Keiko Yata, Magdalena Zernicka-Goetz, Jonathon Pines

Open access · hybridAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 83 citations in OpenAlex.

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  3. MCell death & disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bernhard StraussThe Gurdon Institute, Cambridge, England, UK.
Andrew HarrisonThe Gurdon Institute, Cambridge, England, UK.ORCID 0000-0002-3778-8415
Paula Almeida CoelhoDepartment of Genetics, University of Cambridge, Cambridge, England, UK.ORCID 0000-0003-0614-7575
Keiko YataThe Gurdon Institute, Cambridge, England, UK.ORCID 0000-0001-7648-4898
Magdalena Zernicka-GoetzThe Gurdon Institute, Cambridge, England, UK mz205@cam.ac.uk.
Jonathon PinesThe Gurdon Institute, Cambridge, England, UK jon.pines@icr.ac.uk.ORCID 0000-0002-5227-6004
University of Cambridge · GBInstitute of Cancer Research · GB

Funding

Cancer Research UK 24397Cancer Research UK C6946/A14492Medical Research Council G0701184Medical Research Council G1000818Wellcome Trust 092096
6 · The paper itself

Abstract

There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential for early cell divisions. Cyclin B1 is essential for development, but whether it is required for cell division is contentious. Here, we used a novel imaging approach to analyze Cyclin B1-null embryos from fertilization onward. We show that Cyclin B1

Indexed as

Active Transport, Cell NucleusAnimalscdc25 PhosphatasesCDC2 Protein KinaseCell Cycle ProteinsCyclin B1DNA-Binding ProteinsEmbryonic DevelopmentMiceMice, KnockoutMitosisNuclear ProteinsPhosphorylationProtein-Tyrosine KinasesTranscription FactorsCcnb1 protein, mouseCdc25a protein, mousecdc25 PhosphatasesCDC2 Protein KinaseCdk1 protein, mouseCell Cycle ProteinsCyclin B1DNA-Binding ProteinsMyt1 protein, mouseNuclear ProteinsProtein-Tyrosine KinasesTranscription FactorsWee1 protein, mouse

Identifiers

PMID29074707
PMCPMC5748970
OpenAlexW2766825549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.