Evidence map›Paper›PMID 29074597›Full record

ArticleDiabetes2018

Qingwen Qian, Zeyuan Zhang, Allyson Orwig, Songhai Chen, Wen-Xing Ding, Yanji Xu, Ryan C Kunz, Nicholas R L Lind, Jonathan S Stamler, Ling Yang

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Dysregulated ProteinCirculation research · 2025
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  7. Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline.bioRxiv : the preprint server for biology · 2025
    Article
  8. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases.Journal of Zhejiang University. Science. B · 2025
    Review
  9. Article
  10. Inhalation exposure to airborne PMAmerican journal of physiology. Cell physiology · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Qingwen QianDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center, The Pappajohn Biomedical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA.
Zeyuan ZhangDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center, The Pappajohn Biomedical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA.
Allyson OrwigDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center, The Pappajohn Biomedical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA.
Songhai ChenDepartment of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Wen-Xing DingDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS.
Yanji XuShaun and Lilly International, LLC, Collierville, TN.
Ryan C KunzThermo Fisher Scientific Center for Multiplexed Proteomics, Harvard Medical School, Boston, MA.
Nicholas R L LindDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center, The Pappajohn Biomedical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA.
Jonathan S StamlerInstitute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University and Harrington Discovery Institute, University Hospitals, Cleveland, OH.
Ling YangDepartment of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center, The Pappajohn Biomedical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA ling-yang@uiowa.edu.ORCID 0000-0002-3105-3063
University of Iowa · USDiscovery Institute · USHarvard University · USUniversity of Kansas Medical Center · US

Funding

Integration of Inflammatory Signaling and the Unfolded Protein Response by Nitrosylation Signaling in ObesityR01DK108835 · NIDDK · UNIVERSITY OF IOWA · PI YANG, LING · 2018 to 2022
$1.9M
NIDDK NIH HHS R01 DK108835
6 · The paper itself

Abstract

Obesity is associated with elevated intracellular nitric oxide (NO) production, which promotes nitrosative stress in metabolic tissues such as liver and skeletal muscle, contributing to insulin resistance. The onset of obesity-associated insulin resistance is due, in part, to the compromise of hepatic autophagy, a process that leads to lysosomal degradation of cellular components. However, it is not known how NO bioactivity might impact autophagy in obesity. Here, we establish that

Indexed as

AutophagyInsulin ResistanceAlcohol DehydrogenaseAldehyde OxidoreductasesAnimalsCells, CulturedCysteineDiabetes MellitusDiet, High-FatGene Expression Regulation, EnzymologicGreen Fluorescent ProteinsHepatocytesHumansLysosomesMice, Inbred C57BLMice, KnockoutAdh5 protein, mouseAlcohol DehydrogenaseAldehyde OxidoreductasesCysteineenhanced green fluorescent proteinformaldehyde dehydrogenase, glutathione-independentGreen Fluorescent ProteinsRecombinant Fusion Proteins

Identifiers

PMID29074597
PMCPMC10515702
OpenAlexW2765141222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.